Tag Archives: SMRP

The Best Biomarkers for Mesothelioma Diagnosis, Prognosis, & Monitoring

Best Biomarkers for Mesothelioma

What are the best biomarkers for mesothelioma? The answer is still Soluble Mesothelin-Related Proteins (SMRPs). That is the conclusion of a major review of medical literature by some of the world’s top mesothelioma experts. Dr. Harvey Pass of New York University’s Langone Medical Center and Dr. Michele Carbone of the University of Hawaii are among the authors on the new report.  They analyzed 20 years of research on the best biomarkers for mesothelioma. Several were valuable for mesothelioma prognosis. But SMRPs once again came out the winner for mesothelioma prognosis, diagnosis, and treatment monitoring.  How Do Biomarkers Work? A biomarker is any substance produced by the body that can act as a biological signpost. Proteins usually make the best biomarkers … Continue reading The Best Biomarkers for Mesothelioma Diagnosis, Prognosis, & Monitoring »

Genetics Affect Accuracy of SMRP Test for Mesothelioma

SMRP test for mesothelioma

The SMRP test for mesothelioma is a tool doctors use to help diagnose asbestos cancer and plan treatment. But new research suggests that the test is not as useful as it could be due to genetic variability.  Slovenian doctors say a person’s genetics influence how much SMRP they produce.  Based on their research, they recommend combining the SMRP test for mesothelioma with genetic testing. Their findings suggest the combination method produces a more accurate and useful mesothelioma biomarker. What is the SMRP Test for Mesothelioma? SMRP stands for soluble mesothelin-related peptides. They are produced when proteins found in the mesothelial membranes start to break down. Malignant mesothelioma is one condition that can trigger this breakdown.  As a mesothelioma tumor grows … Continue reading Genetics Affect Accuracy of SMRP Test for Mesothelioma »

Mesothelioma Tumor Progression Can be Tracked With Blood Test

mesothelioma tumor progression

Italian researchers say it’s possible to monitor mesothelioma tumor progression with a simple blood test. They make their case in a Letter to the Editor in the latest edition of the Journal of Thoracic Oncology. The researchers say blood serum levels of the protein mesothelin correlate closely with tumor volume in malignant pleural mesothelioma patients. They are recommending that the blood test be used alongside CT to track mesothelioma tumor progression. The Importance of Monitoring Mesothelioma Tumor Progression Pleural mesothelioma is a rare cancer with a grim prognosis. Mesothelioma tumors tend to grow and spread quickly. Doctors have to carefully monitor mesothelioma tumor progression to tell if a treatment is working. Most mesothelioma patients have chemotherapy with Alimta (pemetrexed) and … Continue reading Mesothelioma Tumor Progression Can be Tracked With Blood Test »

SMRP Still Among Best Diagnostic Biomarkers for Mesothelioma

biomarkers for mesothelioma

Chinese researchers say soluble mesothelin-related peptides (SMRP) in lung fluid is still one of the best biomarkers for mesothelioma, even if it sometimes produces false positives.. SMRP has been studied extensively as a way to help diagnose mesothelioma. The most popular test to check levels of SMRPs in the body is a blood test called MESOMARK. In recent years, other biomarkers for mesothelioma have also emerged. But SMRPs are not just in the blood. A new meta-analysis of SMRPs from pleural effusions finds that they have a valuable place among top biomarkers for mesothelioma. Biomarkers for Mesothelioma: SMRPs and Others Malignant mesothelioma is a type of cancer that starts on the membranes around the lungs, heart or abdomen. SMRPs are … Continue reading SMRP Still Among Best Diagnostic Biomarkers for Mesothelioma »

Research Highlights Connection Between BDNF and Mesothelioma Survival

BDNF and mesothelioma survival

French scientists say there is a clear connection between a biomarker called BDNF and mesothelioma survival. The research may open the door to improved mesothelioma diagnosis, prognosis, and treatment. BDNF stands for brain-derived neurotrophic factor. It is a protein found in the brain and other tissues. In a new published study, researchers at the University of Nantes found that mesothelioma patients had higher BDNF levels than people with other cancers. Mesothelioma patients with the highest BDNF levels had the shortest mesothelioma survival. Linking BDNF and Mesothelioma Survival A biomarker is a substance that can be used to show the presence of disease. BDNF is a soluble mesothelioma biomarker. Soluble biomarkers are in body fluid and can be collected without a … Continue reading Research Highlights Connection Between BDNF and Mesothelioma Survival »