Research Shows Location Impacts Mesothelioma Therapy in Italy

location impacts mesothelioma therapy

Italian cancer researchers have released new data on how patient location impacts mesothelioma therapy in the country.  Pleural mesothelioma is a rare cancer. Most doctors see very few cases in the course of their careers. This lack of expertise may explain why the preferred treatments vary from one region to the next.  Italy’s Scientific Institute for Research, Hospitalization and Healthcare led the new research. They analyzed pleural mesothelioma outcomes across the country. The conclusion is that location impacts mesothelioma therapy in Italy because there is not enough sharing of information. Choosing a Mesothelioma Treatment Approach Pleural mesothelioma is challenging to diagnose and even more difficult to treat. Even experienced mesothelioma doctors often struggle to know the best way to approach … Continue reading Research Shows Location Impacts Mesothelioma Therapy in Italy »

Recommendations for People with a Genetic Predisposition for Mesothelioma

genetic predisposition for mesothelioma

Cancer expects from Ohio State University have just released an updated version of their recommendations for people with a genetic predisposition for mesothelioma.  These people have an inherited mutation on their BAP1 tumor suppressor gene. This mutation puts them at risk for several different types of cancer, including malignant mesothelioma.  It is not possible to prevent cancer in people with this genetic risk factor. But the Ohio State doctors say awareness and screening may help extend the lives of people with a genetic predisposition for mesothelioma.  BAP1 Tumor Predisposition Syndrome BAP1 stands for BRCA association protein 1. The BAP1 gene encodes for the BAP1 protein. BAP1 is one of the proteins that helps keep normal cells from turning into cancer … Continue reading Recommendations for People with a Genetic Predisposition for Mesothelioma »

Radiotherapy Before Mesothelioma Surgery May Not Be Worth the Risk

Radiotherapy before mesothelioma surgery

Cancer doctors at Mayo Clinic say they do not plan to start routinely performing radiotherapy before mesothelioma surgery. The idea is based on a radiation protocol called SMART. The team monitored how well the SMART protocol worked among their pleural mesothelioma patients over a one year period.  The Mayo doctors acknowledged that radiotherapy before mesothelioma surgery can sometimes improve outcomes. But too many of their patients developed serious complications. In a recently-published article, the team concludes that SMART may not be worth the risk for most patients.  The SMART Way to Treat Mesothelioma? Pleural mesothelioma grows on the membrane that surrounds the lungs. Mesothelioma tumors lie close to the lungs and heart and may spread to one or both lungs. … Continue reading Radiotherapy Before Mesothelioma Surgery May Not Be Worth the Risk »

Mesothelioma Clinical Trial Results May Be Skewed by Narrow Inclusion Criteria

mesothelioma clinical trial results

Australian researchers say too many mesothelioma clinical trial results are skewed because they do not include enough “real world” patients.   By “real world patients”, they mean those who fit the profile of the typical mesothelioma patient. The researchers say some of the most important trials limit enrollment to younger people or those with few other health problems.  They say that leaves out a lot of patients. It also makes mesothelioma clinical trial results less relevant in practice.  How Clinical Trials Work Scientists typically test proposed new mesothelioma treatments on isolated cells in a lab first. If the results look promising, they will then run tests in animals to make sure the treatment is safe.   Before a medicine receives approval for … Continue reading Mesothelioma Clinical Trial Results May Be Skewed by Narrow Inclusion Criteria »

Cosmetic Talc Can Cause Mesothelioma, Study Finds

cosmetic talc can cause mesothelioma

A new study in the American Journal of Industrial Medicine appears to offer definitive evidence that repeated exposure to cosmetic talc can cause mesothelioma.  It is an issue that has come up repeatedly in courtrooms in recent years. Lawyers for mesothelioma patients who have used cosmetic talc say the products are unsafe. Manufacturers like Johnson & Johnson insist they are pure.  But the new study shows that may not be the case. If the product is contaminated with asbestos, as many appear to be, the study shows cosmetic talc can cause mesothelioma.  How Can Cosmetic Talc Cause Mesothelioma? Talcum powder is made from talc, which contains magnesium and silicon. Because it absorbs moisture, people use it to keep skin dry … Continue reading Cosmetic Talc Can Cause Mesothelioma, Study Finds »

Possible New Drug for Mesothelioma Gets First FDA Approval

new drug for mesothelioma

A possible new drug for mesothelioma has received FDA approval for the treatment of advanced epithelioid sarcoma.  Tazemetostat (Tazverik) is an oral medication made by a company called Epizyme. It is a brand new kind of drug that blocks a protein called EZH2. Tazemetostat is in testing for several different types of cancer, including malignant mesothelioma.  The recent FDA approval is an encouraging sign that it could one day be a new drug for mesothelioma.  In Search of a New Drug for Mesothelioma  Malignant mesothelioma is one of the most serious consequences of exposure to asbestos. Once asbestos fibers get into the lungs and other tissues, they never leave. Their presence sets up a cascade of cellular reactions that can … Continue reading Possible New Drug for Mesothelioma Gets First FDA Approval »

Surgery Extends Survival for Patients with Pleural Mesothelioma

patients with pleural mesothelioma

Patients with pleural mesothelioma who choose to have surgery live longer than those who do not. This applies no matter which kind of surgery they have.  That is the conclusion of a Mexican study published in the Annals of Oncology. Doctors with the country’s National Institute for Respiratory Diseases conducted the study. It included 122 pleural mesothelioma patients.  The researchers analyzed a wide range of variables like age, sex, asbestos exposure, and overall health. They discovered that the decision to have surgery was one of the most important survival factors in patients with pleural mesothelioma. Treatment Options for Patients with Pleural Mesothelioma Pleural mesothelioma is an aggressive cancer with no known cure. It usually occurs in people who have been … Continue reading Surgery Extends Survival for Patients with Pleural Mesothelioma »

Targeted Radiotherapy for Mesothelioma May Extend Survival in the Right Patients

targeted radiotherapy for mesothelioma

A meta-analysis conducted by some of the country’s top cancer researchers says targeted radiotherapy for mesothelioma can help some people live longer. It is the first such analysis of targeted radiation after lung-sparing mesothelioma surgery. The team focused on intensity modulated radiation therapy (IMRT). IMRT is more precise than earlier forms of radiation treatment.  The new article appears in Practical Radiation Oncology. It is a meta-analysis of ten smaller studies. The researchers conclude that healthier surgery patients could safely consider targeted radiotherapy for mesothelioma. Making Radiotherapy Less Toxic In the past, radiation for mesothelioma has sometimes done more harm than good. Earlier types of radiation treatment were not as precise as IMRT. When radiation spills over into healthy tissue, it … Continue reading Targeted Radiotherapy for Mesothelioma May Extend Survival in the Right Patients »

Can These Compounds Protect Against the Toxic Effects of Asbestos?

toxic effects of asbestos

A recent study out of Australia suggests that compounds called zeolites might offer protection against the toxic effects of asbestos. Asbestos is the primary cause of malignant mesothelioma. Mesothelioma is a rare and aggressive cancer for which there is no cure. There is no way to remove asbestos from the body after a person has been exposed. But the new study suggests that zeolites might counteract some of the toxic effects of asbestos.  If the impact can be validated in humans, it could one day change the outcomes for thousands of people at risk for mesothelioma.  What Are the Toxic Effects of Asbestos? Asbestos is a naturally-occurring mineral made up of long microscopic fibers. The size and shape of these … Continue reading Can These Compounds Protect Against the Toxic Effects of Asbestos? »

Deep Vein Thrombosis After Pleurectomy for Mesothelioma

deep vein thrombosis after pleurectomy

The authors of a new study on deep vein thrombosis after pleurectomy say mesothelioma patients may be at special risk. They say routine screening after pleural mesothelioma surgery could save lives. The study comes from Brigham and Women’s Hospital, a leader in cancer research. The research team followed a series of mesothelioma patients who agreed to be part of a DVT surveillance program.  Nearly 30 percent of the patients experienced deep vein thrombosis after pleurectomy. A third of those patients had no symptoms. Understanding DVT  Deep vein thrombosis or DVT is when a blood clot forms in the deep veins of the arm, leg, or groin. If the clot goes unnoticed, it can travel through the circulation and lodge in … Continue reading Deep Vein Thrombosis After Pleurectomy for Mesothelioma »

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