Mesothelioma Confused with Ovarian Cancer in Women

Mesothelioma Confused with Ovarian Cancer in Women

Malignant peritoneal mesothelioma can easily be confused with ovarian carcinoma in women. This was the case for a 55-year-old woman who went to the hospital for help with abdominal pain, fatigue, and nausea.

Hard to Diagnosis

Mesothelioma is a rare and deadly type of cancer that affects the lining of organs inside the body. When it develops on the lining of the abdominal cavity, it is called malignant peritoneal mesothelioma (MPM). MPM and other types of mesothelioma are caused by exposure to asbestos.

Mesothelioma can be hard to diagnose because the symptoms look just like other common diseases. For MPM, the symptoms could include abdominal pain and swelling, night sweats, and fever. Several diagnostic tests may be needed to reach a definitive diagnosis of MPM.

Imaging scans, such as CT and MRI, can be used to detect tumor masses. Blood tests can be used to detect biomarkers and abnormal substances in the bloodstream. And an abdominal biopsy can be used to obtain a tissue sample and confirm a diagnosis of MPM.

Early Detection and Treatment

In the case described by this new study, doctors examined the woman and found that her stomach was very swollen with fluid. They put a tube in to drain the fluid and ran some tests to find out what was making the woman feel sick.

The doctors found that the woman had low levels of red blood cells and high levels of white blood cells, which can be signs of cancer. They also found that she had high levels of certain proteins in her blood that can be a sign of inflammation in the body.

Based on these initial signs and her medical history, her doctors thought she could have some kind of ovarian cancer. After running some more scans and performing a biopsy, the woman was diagnosed with MPM.

She also had a history of radiation therapy for her thyroid cancer, which may have increased her risk of developing mesothelioma.

This case shows that people who have had radiation therapy for other types of cancer may be at risk for developing mesothelioma. It’s also important for doctors to consider mesothelioma when diagnosing patients with common symptoms. Early detection and treatment might improve survival for these patients.

Source:

Alhamadh MS, Alanazi RB, Wadaan OM, et al. Thrombocytosis as a paraneoplastic syndrome in metastatic malignant peritoneal mesothelioma of biphasic morphology mimicking ovarian adenocarcinoma: A case report. Clin Case Rep. 2023;11(3):e6974. Published 2023 Mar 2. doi:10.1002/ccr3.6974. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979966/

Similar Posts

  • |

    Ape Virus Shrinks Mesothelioma Tumors in Lab

    A virus that causes leukemia in gibbon apes may have the power to help fight malignant mesothelioma in people. Gibbon ape leukemia virus (GALV) has been tested for years as a viral vector, a carrier of therapeutic genetic information, in the treatment of various human illnesses, including cancer. A new study in Japan compared GALV with a leukemia virus derived from mice to see which carrier communicated most efficiently with mesothelioma cells. While both types of viruses replicated in most of the mesothelioma cell lines tested, the mouse-derived virus was not effective in a mesothelioma cell line called ACC-MESO-1. In this cell line, only the GALV spread efficiently both in culture and in mice that had been given human mesothelioma…

  • |

    Mesothelioma Blood Test May Be Possible

    An international team of researchers is studying the proteins found on the surface of cancer cells in an effort to improve mesothelioma diagnosis. The team, made up of scientists from the US, Switzerland, Italy and Chile, has just published their findings on a new kind of test to identify protein-derived mesothelioma biomarkers in blood serum. Mesothelioma is an aggressive cancer of the membranes around organs. Because the most common mesothelioma biomarker, mesothelin, is also overproduced by other kinds of cancer cells, it has only limited diagnostic value. A test to identify a set of proteins produced specifically by mesothelioma cells could greatly improve diagnostic accuracy. Led by Ferdinando Cerciello and Bernd Wollscheid of the Institute of Molecular Systems Biology in…

  • | |

    Needle Biopsy “Simple, Safe & Accurate” for Mesothelioma

    Mesothelioma researchers in China say a biopsy method that involves a single skin puncture can produce good diagnostic results for mesothelioma patients with little pain or risk. The study focused on percutaneous (through the skin) biopsy in patients who had unexplained fluid buildup or swelling in their abdomens. Abdominal distension and fluid buildup (called ascites) can be signs of peritoneal mesothelioma, a rare but aggressive cancer of the abdominal lining caused by exposure to asbestos. Peritoneal mesothelioma accounts for less than 30% of all mesothelioma cases. Because the symptoms may be vague and often develop many decades after asbestos exposure, peritoneal mesothelioma can be especially challenging to diagnose.  Misdiagnosis and under-diagnosis are not uncommon. In the newest study on percutaneous…

  • | |

    Inflammation Both “Friend and Foe” in Mesothelioma

    An immune system response that causes mesothelioma symptoms such as fever, fatigue, and weight loss may also be helpful to clinicians as a way to find and treat the disease. Scientists with The Asbestos Diseases Research Institute in Sydney, Australia make that case that both systemic inflammation (throughout the body) and at the site of a tumor – has long been associated with mesothelioma and other cancers. Inflammation results when the body attempts to address the imbalances of cancer by producing more of certain immune system cells. Some inflammatory markers, such as CD+8 T-cells and C-reactive protein, have been linked to better prognosis in mesothelioma. Other inflammatory markers, such as certain macrophages and a high neutrophil-to-lymphocyte ratio, can signal the…

  • | |

    FDG PET-CT Results Could Lead to Improved Mesothelioma Treatment

    In a recent study, researchers say a better understanding of certain diagnostic criteria could result in more targeted treatments for malignant mesothelioma. In a recent published report, doctors from the medical school at Dicle University in Diyarbakir, Turkey measured the relationship between PET-CT scan results and survival in 177 patients with malignant pleural mesothelioma. The patients were diagnosed between April 2007 and April 2011. They had a mean age of 55.4 and most (56%) were male. Patients in the study all had FDG PET-CT scans before beginning their mesothelioma treatment. FDG PET-CT scanning is a powerful imaging tool for mesothelioma and other cancers that combines a radioactive tracer with a combination of positron emission tomography and computed tomography scanning.  Because…

  • | |

    Mesothelioma Surgeons Report New Biopsy Technique

    A team of surgeons in Maryland have demonstrated how using a standard biopsy tool in a new way could improve the biopsy process for certain mesothelioma patients. An aggressive cancer of the pleural lining around the lungs, malignant pleural mesothelioma usually requires a tissue biopsy to make a definitive diagnosis. Often this is done using a rigid tool called a thoracoscope inserted into the chest wall while the patient is under general anesthesia. However, mesothelioma doctors at Walter Reed National Military Medical Center detail the case of a 79-year-old suspected mesothelioma patient whose biopsy was done in a minimally-invasive way, under conscious sedation, thanks to the novel use of a standard tool. Although the patient had several of the common signs…