Search Results for: epithelioid

Mesothelioma patients who express too much of the protein PD-L1 are less likely to survive the asbestos cancer than those whose cells express less. That is the message from a new Australian study on mesothelioma prognosis, which backs up the findings from a number of previous PD-L1 studies. In a report published in the Asia-Pacific Journal of Clinical Oncology, oncologist Bella Hai Nguyen and colleagues at The Canberra Hospital in Garran analyzed the clinical data on 58 malignant pleural mesothelioma patients treated there between 2006 and 2016. As with previous studies on PD-L1, the Australian study found a link between overexpression of the protein and poor mesothelioma survival. Unlike other studies, though, the new study finds that an even higher…

Tests for the presence or absence of the BAP1 tumor-suppressor protein are likely to continue to play a pivotal role in the diagnosis of malignant mesothelioma. A new evaluation of worldwide studies including more than 1,800 mesothelioma patients found that people who were missing the BAP1 protein almost always had mesothelioma, while those whose cells were still producing BAP1 were not necessarily in the clear. Understanding BAP1 The BRCA1 associated protein 1 (BAP1) gene is responsible for producing a protein (BAP1) that helps suppress the growth of mesothelioma tumors. In some people, the BAP1 gene is mutated, leading to a loss of production of the BAP1 protein. This is known as BAP1 cancer syndrome. People with the BAP1 cancer syndrome…