Tag Archives: aspirin

Aspirin Slows Mesothelioma Growth by Fighting Inflammation

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A group of the world’s top mesothelioma researchers say aspirin may have a role to play in fighting malignant pleural mesothelioma. Aspirin (acetylsalicylic acid or ASA) is an that is known to help reduce the incidence and spread of certain inflammation-related cancers. Mesothelioma, a cancer that starts on the membrane around the lungs and tends to grow and spread quickly, is caused by an inflammatory response to asbestos fibers. That response is related to an inflammatory molecule called high-mobility group box 1 (HMGB1). Researchers at the University of Hawaii Cancer Center, along with colleagues at Cedars Sinai Medical Center in New York and two Italian hospitals theorized that a drug that fights inflammation might fight mesothelioma, too. Using mice infected with … Continue reading Aspirin Slows Mesothelioma Growth by Fighting Inflammation »

NSAIDS Temporarily Stave Off Mesothelioma in Mice

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Aspirin and COX-2 inhibitors like Celebrex will not keep mesothelioma from developing, but they may slow it down a little. That is the conclusion of a team of Australian scientists studying the effects of these drugs on mice and asbestos-exposed people. Both COX-2 inhibitors (pain relievers which act on a specific enzyme responsible for inflammation) and NSAIDS (non-steroidal anti-inflammatory drugs) like aspirin have been associated with a lower incidence of cancer. In addition, because mesothelioma is known to be triggered, in part, by chronic inflammation caused by asbestos fibers, researchers at the National Centre for Asbestos Related Diseases and the School of Public Health at the University of Western Australia theorized that these drugs might be used to prevent mesothelioma. … Continue reading NSAIDS Temporarily Stave Off Mesothelioma in Mice »

Aspirin Derivative No Match for Mesothelioma

aspirin

It may work wonders for aches and pains but apparently the ‘wonder drug’ is no match for the asbestos-linked cancer, malignant mesothelioma. A number of previous studies have suggested a benefit from aspirin for some types of cancer. But Italian scientists testing the aspirin derivative [2-acetoxy-(2-propynyl) benzoate] hexacarbonyldicobalt (Co-ASS) and its analogue hexacarbonyl [μ-(2-ethylphenyl) methanol] dicobalt (Co-EPM) against malignant pleural mesothelioma cells found that both molecules function better as non-steroidal anti-inflammatory (NSAID) agents than as anti-tumor drugs. The researchers tested Co-ASS and Co-EPM against mesothelioma cells of both the more common epithelioid and rarer sarcomatoid types. The most encouraging results were seen with the sarcomatoid cells. Against this cell type, Co-ASS was found to be more potent than either Co-EPM or … Continue reading Aspirin Derivative No Match for Mesothelioma »