There’s more evidence that statin drugs may improve the effectiveness of mesothelioma immunotherapy. The new study, led by Korean biochemists, is not the first to show that these anti-cholesterol medications may help mesothelioma patients. But this one goes a step further to explain why they help. Researchers focused on the impact of statin drugs on PD-1 expression. PD-1 is a protein that protects mesothelioma cells against immune system attack. The findings suggest that, by lowering PD-1 levels, anti-cholesterol drugs may play a greater role in the future of mesothelioma treatment. PD-1 and Mesothelioma Immunotherapy PD-1 is an immune checkpoint protein that occurs on the surface of cells. Normally, it helps keep the immune system from attacking healthy tissues. But mesothelioma … Continue reading Statin Drugs Support Immunotherapy for Mesothelioma, New Study Finds
The cholesterol-lowering drug simvastatin may boost the cancer-killing power of the mesothelioma drug pemetrexed. That news, released by a team of Korean scientists, comes on the heels of another published study showing that the statin drug atorvastatin did not kill mesothelioma in either mice or humans. Although they are primarily used to lower high cholesterol, statin drugs have been shown to have pro-apoptotic properties, meaning they can trigger the dying process in certain cells. An Australian team that recently tested atorvastatin alone found no effect on mesothelioma. But the newest test of a statin for mesothelioma paired the drug simvastatin with the gold-standard chemotherapy drug pemetrexed with more promising results. “We found that the combination of pemetrexed and simvastatin induced more … Continue reading Can Statins Enhance Mesothelioma Treatment?