Tag Archives: EPP

Conservative Surgery Leads to Better Mesothelioma Survival After Recurrence

mesothelioma survival

Mesothelioma survival after recurrence may be better with lung-preserving P/D surgery than with more radical EPP. Japanese researchers recently analyzed the cases of 44 mesothelioma patients who underwent either EPP or P/D. It took about the same amount of time for mesothelioma tumors to start growing again, no matter what type of surgery the patient had. The difference was in survival. Both overall survival and mesothelioma survival after recurrence were longer in the P/D patients. EPP vs. P/D: The Ongoing Debate Mesothelioma surgeons around the world are still divided about which type of mesothelioma surgery is best. On one hand, extrapleural pneumonectomy (EPP) removes more diseased tissue, including a lung. Some say this improves the odds of long term mesothelioma … Continue reading Conservative Surgery Leads to Better Mesothelioma Survival After Recurrence »

Combination Therapy with Mesothelioma Surgery Leads to Longer Survival

Mesothelioma surgery patient with nurse

A new study finds almost a quarter of people who had combination therapy with mesothelioma surgery were still alive five years later. The study was published in the European Journal of Cardio-Thoracic Surgery. Researchers at University Hospitals KU Leuven in Belgium studied nearly 200 mesothelioma patients from 2003 to 2014. Many people do not live beyond about 18 months after a mesothelioma diagnosis. But the Belgian team says, for the right patients, there is a way to improve the odds. They say combination therapy with radical mesothelioma surgery offers a 1 in 4 chance of surviving for 5 years or more. Two Types of Mesothelioma Surgery There are two major schools of thought about mesothelioma surgery. Some surgeons say it … Continue reading Combination Therapy with Mesothelioma Surgery Leads to Longer Survival »

Survival After Mesothelioma Surgery Could Rise with Immunotherapy Spray

improving survival after mesothelioma surgery

A spray-on immune booster may one day improve survival after mesothelioma surgery. UCLA scientists tested the biodegradable spray gel in mice with advanced melanoma. They found that it stopped cancer recurrence after surgery in about half of the lab animals tested. “Around 90 percent of people with cancerous tumors end up dying because of tumor recurrence or metastasis,” says lead investigator Zhen Gu. “Being able to develop something that helps lower this risk for this to occur and has low toxicity is especially gratifying.” Gu is a professor of bioengineering and a member of the UCLA Jonsson Comprehensive Cancer Center where the spray was developed. Survival After Mesothelioma Surgery Survival after mesothelioma surgery or any other kind of cancer operation … Continue reading Survival After Mesothelioma Surgery Could Rise with Immunotherapy Spray »

Better Quality of Life from Lung-Sparing Mesothelioma Surgery

blowing

Mesothelioma patients who undergo pleurectomy/decortication (P/D) may enjoy a better quality of life afterward than those who have extrapleural pneumonectomy (EPP). That is the message of a new study published in the Asian Cardiovascular and Thoracic Annals. Pleural mesothelioma arises most often in the thin lining that surrounds the lungs. Because of its close proximity to the lungs, it is not uncommon for pleural mesothelioma to eventually spread to the lung itself, reducing its function. Eventually, the diseased mesothelium also thickens and stiffens, preventing the lungs from expanding adequately with each breath. Pleurectomy/decortication and extrapleural pneumonectomy are the two major types of surgical treatments for mesothelioma. There is great disagreement within the medical community as to which one is better for … Continue reading Better Quality of Life from Lung-Sparing Mesothelioma Surgery »

Mesothelioma Study Suggests Trimodal Falls Short

A team of Swiss doctors have added their names to the list mesothelioma experts who believe that the intense trimodal treatment approach including extrapleural pneumonectomy (EPP) is not the best choice for most patients. Malignant mesothelioma is a cancer that starts in the membranes around organs, most often the lungs. Extrapleural pneumonectomy (EPP) is a radical surgical approach for pleural mesothelioma that includes removing not only the diseased mesothelium but also the nearest lung, other body linings, and all or part of the diaphragm. It is often preceded by chemotherapy and followed by radiotherapy.  Although this trimodal approach carries a high risk of serious complications and even death, it has resulted in long term survival for some mesothelioma patients. Even with aggressive … Continue reading Mesothelioma Study Suggests Trimodal Falls Short »

New Study Finds EPP Improves Mesothelioma Quality of Life

Surgery for Peritoneal Mesothelioma

New research out of Italy casts another vote in favor of the controversial and radical surgical approach known as extrapleural pneumonectomy (EPP) for treating mesothelioma. Pleural mesothelioma occurs in the pleural membrane which separated the lungs from other internal organs. As the cancer spreads, it restricts the ability of the lungs to expand. Eventually, pleural mesothelioma can spread into the lungs themselves and other internal membranes. Extrapleural pneumonectomy attempts to prevent metastasis by removing the tissues most likely to be effected, including the lung lining, part of the pericardium (lining around the heart), a portion of the diaphragm, and the diseased lung. Because EPP is so radical and so risky (it carries a 60 percent complication rate), many of the … Continue reading New Study Finds EPP Improves Mesothelioma Quality of Life »

Radiotherapy and EPP is a Winning Combo for Some Mesothelioma Patients

Another study has confirmed the value of radiotherapy as an adjuvant treatment for mesothelioma patients who undergo extrapleural pneumonectomy. A team of Italian researchers recently analyzed the records of 56 mesothelioma patients who had been treated with adjuvant radiotherapy after extrapleural pneumonectomy surgery (EPP) between 2005 and 2010. Caused by exposure to asbestos, malignant mesothelioma is a fast-growing cancer of the mesothelial lining around the lungs and other organs. Extrapleural pneumonectomy is a radical surgical procedure that involves removing not only the mesothelioma tumors, but also the lung closest to the tumor and a portion of the diaphragm. Although EPP is controversial due to its high rate of complications, a number of studies have shown it to increase survival, especially … Continue reading Radiotherapy and EPP is a Winning Combo for Some Mesothelioma Patients »

Mesothelioma Experts Take Aim at Radical Surgery

There is disagreement among some of the world’s top mesothelioma experts about the value of the radical surgical treatment known as extrapleural pneumonectomy (EPP). An asbestos-linked malignancy, pleural mesothelioma grows in a thin sheet across the membranous tissue surrounding the lungs. The cancer may eventually spread to the lung tissue, as well. Fluid buildup and stiffening off the mesothelium by the tumor cells makes it impossible for the lungs to expand normally. Introduced in the 1940’s and modified over the years, EPP involves removal of not only the diseased pleural tissue, but the lung closest to it, the lymph nodes, and portions of the covering of the heart (pericardium) and the diaphragm. Despite a 60 percent complication rate, the radical … Continue reading Mesothelioma Experts Take Aim at Radical Surgery »

Surgery is Inappropriate for Some Mesothelioma Patients

Patients with non-epithelial mesothelioma and lymph node involvement are poor candidates for the extensive surgical procedure known as extrapleural pneumonectomy (EPP), according to a new study. That’s the finding of a new article published in the Annals of Surgical Oncology. Researchers from the Baird Institute for Applied Heart and Lung Surgical Research in Sydney, Australia analyzed the current literature on EPP for malignant pleural mesothelioma. They examined the patient selection process and overall survival of surgical patients in major referral centers where EPP is performed. The most serious of the asbestos cancers, mesothelioma tends to spread quickly and is notoriously resistant to standard treatments. Clinical trials across the globe have confirmed that the best mesothelioma outcomes are seen in patients … Continue reading Surgery is Inappropriate for Some Mesothelioma Patients »