Tag Archives: genetic mutation

Genetic Mutation Improves Mesothelioma Survival Odds

Another new study has been released that supports the idea that mesothelioma patients who are missing the tumor suppressor called BAP1 are more likely to survive longer than those who have intact BAP1 genes. The BRCA-1-associated protein 1 (BAP1) gene is located on the chromosome 3p21. Because the job of BAP1 is to help suppress cancer, a mutation that causes this gene to be inactive raises the risk that a person could get mesothelioma or another cancer. BAP1 loss has also been associated with increased risk of skin cancer, renal cell cancer and some lung and breast cancers. But there appears to be an upside to BAP1 loss. Data published in the journal Pathology suggests that mesothelioma patients with BAP1 … Continue reading Genetic Mutation Improves Mesothelioma Survival Odds »

BAP1 Mutation May Bode Well for Mesothelioma Survival

A new study has some good news and some bad news for people who carry the BAP1 genetic mutation. The bad news is that they have a significantly higher risk of contracting malignant mesothelioma and several other types of cancer than people without this genetic mutation. The good news is that, people with the BAP1 mutation who do get mesothelioma, have a seven-fold increase in long-term survival over mesothelioma patients without this genetic anomaly.   Now, a multicenter study involving the University of Hawaii Cancer Center, the Samuel Oschin Comprehensive Cancer Institute-Cedars-Sinai in Los Angeles, the Hofstra-North Shore LIJ School of Medicine in New York, and the New York University Langone Medical Center finds that BAP1 mesothelioma may actually be more survivable. … Continue reading BAP1 Mutation May Bode Well for Mesothelioma Survival »

Genetic Mutation Linked to Mesothelioma

Medical science may finally be a step closer to understanding why some people exposed to asbestos contract malignant mesothelioma and others do not. A new study funded by the National Cancer Institute and conducted by researchers at Fox Chase Cancer Center in Philadelphia and the University of Hawaii Cancer Center has found that people who have a genetic mutation on their BAP1 gene are more susceptible to mesothelioma and several other types of cancer. The study, published in a recent issue of Nature Genetics, followed two families that have an unusually high incidence of mesothelioma, which is typically very rare. In the U.S., mesothelioma affects fewer than 3,000 people each year. This, despite the fact that tens of thousands of … Continue reading Genetic Mutation Linked to Mesothelioma »