mesothelioma

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    A New Test for Mesothelioma?

    ByAlex Strauss

    Malignant pleural mesothelioma, an aggressive cancer of the pleural membrane that encases the lungs, can be difficult to diagnose.  Early symptoms of the disease can be vague and mimic other lung conditions.  But the longer a patient goes without a firm diagnosis, the poorer the prognosis is likely to be since mesothelioma is resistant to many traditional therapies. In addition to considering the patient’s symptoms and history of asbestos exposure, doctors often rely on biomarkers – compounds found in the blood or lung fluid – to pinpoint mesothelioma. Now, a group of Danish scientists are investigating a new biomarker that may eventually allow for an earlier, more accurate, mesothelioma diagnosis. Methylthioadenosine phosphorylase (MTAP) is a key enzyme used to help cells…

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    Spice May Trigger Mesothelioma Cell Breakdown

    ByAlex Strauss

    There’s more evidence that cancer researchers might do well to spice up their mesothelioma clinical trials. A team of researchers at Keio University in Tokyo report that curcumin, the primary component in the spice turmeric, can effectively reduce the viability of human mesothelioma cells in the laboratory. This, despite the fact that mesothelioma is notoriously resistant to many types of conventional cancer therapies. “Curcumin, which has a long history as a dietary spice, is known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well-defined,” observed principal investigator Y. Yamauchi in Phytotherapy Research. Mesothelioma is an aggressive cancer of internal membranes, triggered by asbestos exposure. Citing mesothelioma’s well-known treatment resistance, Yamauchi says alternative…

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    New Radiotherapy Technique May be Safer for Mesothelioma

    ByAlex Strauss

    There’s more evidence that an advanced method for delivering radiotherapy may improve survival for mesothelioma patients after surgery. Extrapleural pneumonectomy (EPP) is a surgical procedure for malignant pleural mesothelioma that involves removing the mesothelioma tumor, as well as the pleural lining where the tumor is located, the nearest lung, all or part of the diaphragm, and other internal membranes. It is often followed by adjuvant radiotherapy to kill remaining tumor cells. Because the radiation target area in post-operative mesothelioma patients is irregular in shape and located close to critical internal organs, many patients receive a targeted type of radiotherapy called intensity modulated radiation therapy (IMRT). But postoperative IMRT also carries a high risk of a potentially fatal lung condition called…

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    Is Mesothelioma Hereditary?

    ByAlex Strauss

    Could susceptibility to mesothelioma pass from parent to child through the genes? That is a question Greek scientists are trying to answer as they try to determine why some families seem to be ‘prone’ to mesothelioma. Although many other cancers are known to have a hereditary component, mesothelioma is unique in that it is known to be caused by exposure to the mineral asbestos. Inhaling or ingesting asbestos fibers can trigger a series of physiological changes that leads to mesothelioma years later. In most cases where multiple members of a family are diagnosed with mesothelioma, they are all found to have been exposed to asbestos. Children are sometimes exposed to the asbestos on a parent’s work clothes. Or several members…

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    Italy Verdict May Have Worldwide Mesothelioma Impact

    ByAlex Strauss

    Advocates of better protection for workers from mesothelioma and other occupational diseases have won a major court victory. A Swiss billionaire and a Belgian executive – both former managers in the Italian affiliate of the Eternit cement company – have been sentenced to 16 years in jail and ordered to pay millions of Euros for negligence that led to more than 2,000 deaths from mesothelioma and other asbestos-related diseases. The Reuters news agency predicts that the decision, announced in Turin, Italy, could “set a precedent for proceedings worldwide about safety in the workplace.” Stephan Schmidheiny was a former owner of the cement company and Jean Louis Marie Ghislain de Cartier de Marchienne was a shareholder and former manager in the…

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    Proton Therapy – “Clear Advantages” in Treating Mesothelioma

    ByAlex Strauss

    A new study suggests that an up-and-coming type of radiotherapy may do more good – with less damage – than the current gold standard radiation treatments for mesothelioma. Currently, most mesothelioma patients who are treated with radiotherapy receive the conventional electron-based variety. While radiation can sometimes shrink a tumor, one of the major risks is that the ionized particles will also do permanent damage to the healthy tissue around it. This can be particularly challenging in mesothelioma because the tumors tend to be thin, spread across a large area, and are located close to critical organs such as the heart and lungs. Like electron-based radiotherapy, proton-based radiotherapy works by ionizing radiation to kill cancer cells and shrink tumors. But in…

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    Harnessing T-Cells to Fight Mesothelioma

    ByAlex Strauss

    Cancer researchers in Australia are harnessing the power of disease-fighting T-cells in the ongoing battle with mesothelioma. Mesothelioma is a virulent cancer of the membrane that surrounds the lungs and lines the abdomen. The response of the body’s immune system to mesothelioma and other cancers is complex. Mesothelioma tumors in mice and people produce large numbers of Regulatory (Treg) T cells. While Treg cells are typically thought of as one of the body’s ways of fighting disease, the latest research suggests that, in some cases, turning these cells ‘off’ might be more effective against cancer than letting them do their job. In the newest study of Treg cells, they were shown to act as important “mediators” of the body’s anti-tumor…

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    Common Cold Virus – Uncommon Mesothelioma Treatment

    ByAlex Strauss

    Researchers at the University of Pennsylvania are fighting malignant mesothelioma with an unexpected tool – the cold virus. The approach fits into a category of treatment known as immunotherapy, which aims to harness the body’s own immune system to find and attack cancer cells. In the current study, Penn Medicine mesothelioma researchers, led by Steven Albelda, MD, and Daniel Sterman, MD, of the Pulmonary, Allergy, and Critical Care Division, injected mesothelioma patients with a modified form of the adenovirus – a virus normally associated with the common cold. The virus had been altered to express high levels of an immune system stimulant called Interferon-a, a protein that can boost the body’s ability to fight off viral infection. Nine mesothelioma patients…

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    Navy Did Not Protect All Veterans from Mesothelioma

    ByAlex Strauss

    Calling it one of the “most knowledgeable organizations in the world regarding the health hazards of asbestos,” a San Francisco-based chemical risk assessment company says that the U.S. Navy was ahead of the curve in attempting to protect veterans and civilians from mesothelioma in the 1960’s.  Ships of that era were heavily laden with asbestos, making Navy veterans among the most common victims of mesothelioma, the most serious of the diseases caused by asbestos exposure. But according to Kara Franke and Dennis Paustenbach who examined dozens of published and unpublished documents on asbestos knowledge from 1900 to 1970, the Navy understood the health hazards of asbestos as early as the 1930’s. Although they continued to require its use on ships, the Navy…

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    Demolition May Raise Mesothelioma Risk

    ByAlex Strauss

    Do not take the dangers of asbestos for granted. That warning comes directly from the Environmental Protection Agency (EPA) which admits to having done exactly that when it experimented with relaxing some of its own regulations for safe asbestos handling. EPA began regulating asbestos use after the material was linked to mesothelioma and a range of other health problems in the 1960’s. Airborne asbestos fibers can lodge in the lungs, triggering mesothelioma even decades after exposure. Despite the danger, beginning in 1999, EPA considered alternative methods to “augment” the Asbestos National Emission Standards for Hazardous Air Pollutants, the act that governs asbestos handling during demolition. The alternative methods considered, including the Fort Worth Method and the Alternative Asbestos Control Method, leave some…