Tag Archives: mesothelioma treatment

Rare Form of Mesothelioma Appears after Multimodal Treatment

Advanced mesothelioma treatment approaches like multimodal therapy may not only prolong survival in some patients; they may also cause fundamental changes in the way the disease presents itself. Pleural mesothelioma is a malignancy of the thin lining that encases the lungs. It is caused by exposure to asbestos. Typically, the prognosis is poor. But a multinational study in the Journal of Thoracic Oncology finds that more efficient chemotherapy protocols and aggressive management strategies are resulting in more longer-living patients. The researchers single out the powerful trimodal combination of induction chemotherapy, extrapleural pneumonectomy surgery, and adjuvant high-dose hemithoracic radiation for its impact on survival. Although this therapy combination may hold mesothelioma at bay in some cases, it usually returns eventually. The … Continue reading Rare Form of Mesothelioma Appears after Multimodal Treatment »

Multi-Modality Mesothelioma Treatment Well Tolerated

The combination of pleurectomy/decortication, hyperthermic pleural lavage and adjuvant chemotherapy is an effective alternative to more traditional mesothelioma treatment combinations. So say the London scientists who tested the method on 36 mesothelioma patients over a five-and-a-half year period. The mesothelioma patients were all treated at a London hospital between October 2004 and May 2010. Each patient first underwent pleurectomy/decortication, a surgical method for removing as many malignant mesothelioma tumor cells as possible. The method is considered by many to be a safer alternative to the more extensive surgery called extrapleural pneumonectomy, which involves removing a lung and part of the diaphragm. Before their surgical wounds were closed, each patient’s chest cavity was rinsed with a warmed povidone-iodine solution, designed to … Continue reading Multi-Modality Mesothelioma Treatment Well Tolerated »

Genes May be Targets for Mesothelioma Treatment

The same genes that can help predict which mesothelioma patients will do well after surgery, might also be good targets for gene therapy to combat the disease. That’s the conclusion of one of the nation’s top mesothelioma experts, Dr. David Sugarbaker, and his colleagues at Brigham & Women’s Hospital in Boston. After publishing research showing that certain genes can affect patients’ post-surgical prognosis, the team looked further into the genes themselves and how they relate to mesothelioma. Mesothelioma is highly resistant to standard treatments. Gene therapy, which harnesses and uses the body’s own nature defense system, is being studied as a promising alternative. Starting with lung tissue from both healthy patients and those with malignant pleural mesothelioma, the researchers used … Continue reading Genes May be Targets for Mesothelioma Treatment »

German Mesothelioma Treatment Keeps U.K. Man Alive

An advanced new mesothelioma treatment developed in Germany is credited for keeping a British man alive – four times longer than he was expected to live. Sixty-five year old Keith Turnbull of Hertfordshire contracted mesothelioma in 2008 because of asbestos from his father’s worth clothes. Mesothelioma is an aggressive cancer that is highly resistant to traditional treatments. At the time of his diagnosis, doctors did not expect Turnbull to live beyond six months. But after 13 trips to Germany to received transarterial chemoembolization, Turnbull is still alive, two and a half years later. Transarterial chemoembolization, pioneered by German Professor Thomas Vogl of the J.W. Goethe University Hospital in Frankfurt, attacks tumors from two directions – simultaneously cutting off their blood … Continue reading German Mesothelioma Treatment Keeps U.K. Man Alive »

Mesothelioma Treatment Becoming More Individualized

A respected team of mesothelioma experts predicts that treatment for this aggressive cancer will become increasingly personalized in the next five to ten years. A malignancy in the lining around the lungs and other organs, mesothelioma is caused almost exclusively by asbestos exposure. Although its occurrence in the U.S. is believed to have leveled out at about 3,000 cases per year, the number of cases around the world is continuing to increase. Because the disease is so difficult to treat, many patients succumb within a year of diagnosis, even with the best therapies now available. For this reason, researches continue to look for ways to predict which treatments are most likely to work for which patients. In a recent article … Continue reading Mesothelioma Treatment Becoming More Individualized »

Mesothelioma Treatment Research

Targeting Mesothelioma Stem Cells with FAK Inhibitors

Mesothelioma treatment today is basically made up three options: surgery, chemotherapy, or radiation. More targeted therapies that address the biological factors triggering mesothelioma growth might be a much more precise and effective way to combat this difficult-to-treat cancer, according to a recent article in Connective Tissue Research. Mesothelioma is so challenging to treat because it is often diagnosed at a late stage, and because it can take many biological forms. Current mesothelioma treatments were originally designed for other types of cancers, without considering factors that may be specific to mesothelioma. That may be why many patients only partially respond to treatment, and the average survival is just 12 months after diagnosis. The key to prolonging the lives of mesothelioma patients … Continue reading Mesothelioma Treatment Research »