If one cytoreductive surgery and HIPEC procedure for mesothelioma is good, subsequent treatments may be even better. That is the central message of research conducted at the Moffitt Cancer Center in Florida. The study’s aim was to assess overall survival among peritoneal mesothelioma patients who had not just one, but two or more rounds of heated intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery. The cytoreduction/HIPEC approach has become popular for peritoneal mesothelioma, a treatment-resistant cancer of abdominal membranes caused by asbestos. Cytoreductive surgery involves removing as much of the mesothelioma tumor as possible from the abdomen. Because the shape and spreading pattern of mesothelioma tumors make complete cytoreduction difficult, the surgery is often followed by a rinse with a heated solution … Continue reading Repeat HIPEC Improves Mesothelioma Survival
New research conducted in Italy and presented at the 15th World Conference on Lung Cancer in Sydney, Australia suggests that mesothelioma surgery – no matter what kind – may not offer a survival advantage over medical management for the healthiest of patients. Mesothelioma is a rare but aggressive malignancy that is highly resistant to standard cancer treatments. The two types of mesothelioma surgery considered to be options for people with resectable cancer are pleurectomy decortication (P/D) or extrapleural pneumonectomy (EPP). While EPP is more radical than P/D because it involves removing a lung, both carry a heavy risk of complications and, according to the Italian researchers, may not be of value for certain patients. The study reviewed data from 1,365 … Continue reading Value of Mesothelioma Surgery Challenged for Healthy Patients
Cancer researchers at Wake Forest University have found another benefit to the cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) combination used to treat peritoneal mesothelioma and other abdominal cancers: the control of fluid buildup. Fluid accumulation in the abdomen because of peritoneal mesothelioma or another type of cancer is known as ascites. Left untreated, ascites can cause bloating, discomfort, disfiguration, and shortness of breath when it interferes with the movement of the diaphragm. While patients with peritoneal mesothelioma, an aggressive cancer of the peritoneal surface, can have this fluid drained off, it often reaccumulates. But the new Wake Forest research suggests that CRS/HIPEC may offer a more permanent solution. Fifteen percent of the cancer patients in the study had … Continue reading Mesothelioma Surgery May Have Added Benefit
A new analysis of pleurectomy/decortication suggests that the most radical form of the surgery produces the best results for mesothelioma patients, but also carries the greatest risk. Pleurectomy/decortication or P/D involves the removal of the pleural lining where malignant mesothelioma grows. Removing all or part of the lining frees up the lungs to expand again, relieving life-limited mesothelioma symptoms such as shortness of breath. But, as the Australian researchers found in their mesothelioma analysis, the varying degrees of P/D can make it difficult to accurately compare the method to the more extensive lung-removing surgery or even to get an accurate picture of P/D outcomes. Extended or ‘radical’ P/D involves removing the entire pleural lining, while partial P/D involves removing only part … Continue reading P/D for Mesothelioma: Are the Studies Accurate?
Peritoneal mesothelioma patients who have cytoreductive surgery (CRS) and heated chemotherapy can sometimes benefit from a second surgery, but it may be harder the second time around. Researchers in France have recently published their findings in a study of patients with mesothelioma and other peritoneal cancers who experienced recurrence after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Peritoneal mesothelioma is an asbestos-related malignancy that spreads across the peritoneum, the membrane that lines the abdomen. For patients who are healthy enough to undergo it, cytoreductive surgery to remove as much of the cancer as possible, followed by a solution of heated chemotherapy drugs, has been shown to improve survival. But the French team wanted to examine the possible options for people … Continue reading Mesothelioma Study Cites Risks & Benefits of Second Surgery
Doctors in the Department of Respiratory medicine at York Teaching Hospital in the UK are taking a hard stance against the surgical treatment of malignant pleural mesothelioma. In a recent article in the journal Thorax, the group contends that the research surrounding mesothelioma surgery is largely flawed and that the majority of mesothelioma patients would be better served if their doctors suggested alternatives. “Belief that the modest survival times reported after radical surgery, whether alone or as part of multimodal therapy, are longer than they would have been without surgery relies on data from highly selected, uncontrolled, retrospectively analyzed case series,” they write. They point out that the only randomized study, the Mesothelioma and Radical Surgery (MARS) trial showed no measurable … Continue reading Mesothelioma Report Suggests Clinical Trials Better Than Surgery
A distinguished group of experts in lung-sparingmesothelioma treatment techniques say there is more reason than ever for patients with this deadly cancer to be hopeful. Robert Cameron, MD, Director of the UCLA Mesothelioma Comprehensive Research Program and Chief of Thoracic Surgery at West Los Angeles VA Medical Center recently led the 3rd annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma in Santa Monica. Hosted by UCLA and the Pacific Heart, Lung and Blood Institute, the symposium made international news two years ago when its participants declared there was “no place” for extrapleural pneumonectomy (EPP – a lung-removing surgery) in the treatment of mesothelioma. Despite its high mortality rate, EPP is still supported by some mesothelioma experts for its ability … Continue reading Mesothelioma Lung-Sparing Proponents Increase
A Chandler, Arizona man is recovering after becoming the second person in the world to undergo robotic surgery for mesothelioma. Carlos Tarazon, a 67-year-old former construction worker, was diagnosed with malignant pleural mesothelioma after spending more than 20 years in the construction industry. He had exhausted his treatment options when he was referred to University of Arizona Medical Center thoracic surgeon Farid Gharagozloo, MD, who elected to perform robotic-assisted extrapleural pneumonectomy (EPP). Gharagozloo had performed the world’s first robotic EPP just days before. Pleural mesothelioma invades organ membranes, the chest well, and, often, the lungs. EPP involves removing not only the diseased lung lining, but also the lung itself, portions of the chest wall, the membrane around the heart, and all … Continue reading Can Robotics Make Mesothelioma Surgery Safer?
Completeness of surgery, tumor grade, and the use of the chemotherapy drug cisplatin all have an impact on survival after peritoneal mesothelioma surgery and heated intraoperative chemotherapy, according to recent studies. Peritoneal mesothelioma is a cancer of the abdominal wall. This type of mesothelioma is often treated by surgery to remove as much of the cancer as possible (Cytoreductive surgery or CRS) followed by a wash of heated chemotherapy drugs through the open body cavity (HIPEC). Two recent studies – one conducted in the U.S. and one in Singapore – have independently confirmed a list of factors that contribute to survival after CRS and HIPEC for peritoneal mesothelioma. The first study included 211 peritoneal mesothelioma patients treated with CRS and HIPEC at … Continue reading Studies Confirm Success Factors for Mesothelioma Surgery
Mesothelioma patients who undergo pleurectomy/decortication (P/D) may enjoy a better quality of life afterward than those who have extrapleural pneumonectomy (EPP). That is the message of a new study published in the Asian Cardiovascular and Thoracic Annals. Pleural mesothelioma arises most often in the thin lining that surrounds the lungs. Because of its close proximity to the lungs, it is not uncommon for pleural mesothelioma to eventually spread to the lung itself, reducing its function. Eventually, the diseased mesothelium also thickens and stiffens, preventing the lungs from expanding adequately with each breath. Pleurectomy/decortication and extrapleural pneumonectomy are the two major types of surgical treatments for mesothelioma. There is great disagreement within the medical community as to which one is better for … Continue reading Better Quality of Life from Lung-Sparing Mesothelioma Surgery