Tag Archives: T-cells

Mesothelioma Study Finds New Treatment Target

physician and colleagues

Immunotherapy, which involves reprogramming T-cells to find and attack cancer cells, is one of the fastest-growing areas of cancer research. One of the biggest challenges of immunotherapy is how to harness the power of T-cells against cancer without also turning them against healthy cells. A new study conducted in Switzerland and published in the Journal of Translational Medicine addressed the problem by reprogramming T-cells to recognize and attack mesothelioma cells that express a specific protein. Fibroblast Activation Protein (FAP) is expressed on the surface of tumor-associated fibroblast cells which are found in the connective tissue of mesothelioma tumors. FAP is also found in mesothelioma cells and may play a role in the start of cancer, as well as the growth … Continue reading Mesothelioma Study Finds New Treatment Target »

T-Cells Can Predict Mesothelioma Treatment Success

Mesothelioma patients whose T-cell counts bounce back quickly after a round of chemotherapy have a better chance of survival. They are also most likely to benefit from the addition of immunotherapy. That’s the conclusion of a British study looking for prognostic indicators in mesothelioma patients undergoing a combination of chemotherapy. Noting that there is increased interest in pairing chemotherapy with immunotherapy, the group was also looking for a method of determining who would benefit most from the combination. Chemotherapy is the most common first-line treatment for mesothelioma. It involves flooding the body with a drug or combination of drugs designed to destroy cancer cells. Immunotherapy involves “programming” the immune system to recognize cancer cells as foreign invaders and attack them the … Continue reading T-Cells Can Predict Mesothelioma Treatment Success »

Harnessing T-Cells to Fight Mesothelioma

Cancer researchers in Australia are harnessing the power of disease-fighting T-cells in the ongoing battle with mesothelioma. Mesothelioma is a virulent cancer of the membrane that surrounds the lungs and lines the abdomen. The response of the body’s immune system to mesothelioma and other cancers is complex. Mesothelioma tumors in mice and people produce large numbers of Regulatory (Treg) T cells. While Treg cells are typically thought of as one of the body’s ways of fighting disease, the latest research suggests that, in some cases, turning these cells ‘off’ might be more effective against cancer than letting them do their job. In the newest study of Treg cells, they were shown to act as important “mediators” of the body’s anti-tumor … Continue reading Harnessing T-Cells to Fight Mesothelioma »