Tag Archives: treatment options

Understanding Treatment Options for Malignant Pleural Mesothelioma

Understanding Treatment Options for Malignant Pleural Mesothelioma

Malignant pleural mesothelioma is a rare type of cancer and standard therapies are limited. Therefore, most patients consider one or more of three treatment options. These paths use different types of therapies and they are usually not exclusive. Mesothelioma patients can move from one type to another and, if their doctors agree, can sometimes use them in combination. A new publication gives an overview of the best treatment options currently available for malignant pleural mesothelioma. Standard therapies include chemotherapy, radiation, and surgery. If more than one of these therapies is used it is may be called multi-modality therapy. Oncologists are the doctors who provide chemo and radiation. Of course, surgeons provide surgeries. Understanding the Mesothelioma Diagnosis Malignant pleural mesothelioma is a … Continue reading Understanding Treatment Options for Malignant Pleural Mesothelioma »

Predicting How a Patient Will Respond to Mesothelioma Treatment

Predicting How a Patient Will Respond to Mesothelioma Treatment

Malignant pleural mesothelioma is a rare cancer. Early diagnosis is challenging. Treatments are the first clinical option in the advanced disease stage. A doctor’s initial clinical response says a lot about the patient’s prognosis. It may even represent a useful way to identify patients with a better long-term outcome. A new Italian study from the Journal of Clinical Medicine looks at this possibility. First Mesothelioma Treatment Response Options Scientists looked at the initial treatment response in 46 mesothelioma patients who had pleural mesothelioma. None of these patients had surgery as an option because their tumors were considered inoperable. The doctor’s initial treatment response included a CT scan and clinical examination. This examination was usually after 2–3 cycles of drug therapy. … Continue reading Predicting How a Patient Will Respond to Mesothelioma Treatment »

First-Line Chemotherapy versus Immunotherapy versus Maintenance Therapy

Chemotherapy versus Immunotherapy versus Maintenance Therapy

A recent study compared mesothelioma patients’ survival by physician’s choice of treatment. Is first-line chemotherapy the best choice? Malignant pleural mesothelioma is an aggressive cancer that affects older adults. Mesothelioma patients often have other comorbidities making real-world treatment decisions challenging. The first was by choice of first-line chemotherapy. The second was the physician’s choice of second-line chemotherapy versus immunotherapy. And the third was by the physician’s choice of use of maintenance therapy. Physician’s Choice of First-Line Chemotherapy Drugs This is the largest real-world study of U.S. patients diagnosed with mesothelioma. Scientists analyzed physicians’ choice of first-line chemotherapy, second-line therapy, and maintenance therapy. In the first-line chemotherapy analysis, there was no significant difference in patient survival. As of this writing, the only … Continue reading First-Line Chemotherapy versus Immunotherapy versus Maintenance Therapy »

Treatment Options Improving in the ‘New Era’ for Mesothelioma

treatment options

Calling it a “new era” for malignant pleural mesothelioma, doctors from four of the nation’s top cancer centers have just published an update on treatment options for this rare disease.  The article was prepared by mesothelioma experts at MD Anderson Cancer Center in Texas, NYU Langone Medical Center, Memorial Sloan Kettering Cancer Center in New York and the Mayo Clinic in Minnesota.  The article in the Journal of Clinical Oncology highlights the recent FDA approvals of a new medical device and a new immunotherapy combination for pleural mesothelioma. The authors say these and other advances are “generating momentum” to find better mesothelioma therapies.  Tumor Treating Fields Changing the Game Pleural mesothelioma is fast-growing and difficult to treat. Mesothelioma rarely responds … Continue reading Treatment Options Improving in the ‘New Era’ for Mesothelioma »

Orphan Drug Approval Could Mean New Mesothelioma Treatment Option

A drug designed to fight cancer by destroying the stem cells that give rise to new cancer cells has been granted orphan drug status for the treatment of malignant mesothelioma. The designation paves the way for mesothelioma patients, who often have few treatment options, to get access to VS-5584 earlier than it would otherwise be available. VS-5584 is a powerful inhibitor of a signaling pathway that regulates cancer progression and the survival of cancer stem cells. According to Verastem, the Boston-based maker of VS-5584, the drug has already received a similar designation for mesothelioma in Europe. “This is an important regulatory milestone for Verastem and… will facilitate our global development of VS-5584 to help improve the available treatment options for patients suffering … Continue reading Orphan Drug Approval Could Mean New Mesothelioma Treatment Option »

Mesothelioma Treatment May Get Boost From Immune Therapy

Therapies that trigger an immune response against mesothelioma tumors could potentially enhance the effectiveness of current treatments, but more research is still needed to find the most effective way to deliver these immune therapies, according to a study published online in the journal, Interactive Cardiovascular and Thoracic Surgery. Because mesothelioma is such a difficult cancer to treat, doctors typically take a multi-faceted approach, using a combination of surgery, chemotherapy, and radiation. Yet even when combined, these therapies achieve only minimal success and patients often face a grim prognosis. In their search for new and better treatment options, researchers have started to focus on therapies that stimulate the body’s own immune response against the cancer. In both animal and human studies, … Continue reading Mesothelioma Treatment May Get Boost From Immune Therapy »