The Power of First-in-Human Trials: A Glimpse into Zelenirstat’s Impact on Mesothelioma

The Power of First-in-Human Trials: A Glimpse into Zelenirstat's Impact on Mesothelioma

The journey towards a breakthrough cancer treatment often begins with groundbreaking trials. Zelenirstat is a cutting-edge drug currently under study. It has shown promise in its first-ever trial involving mesothelioma patients. These are significant first steps in paving the way for potential new treatments.

A First-In-Human Trial

Scientists are exploring a new treatment, Zelenirstat for tough cancers like mesothelioma. They tested this treatment on 21 patients with various cancers. This was in a special trial called a “first-in-human” trial. They gave different doses of Zelenirstat, starting from 20 mg to 280 mg every day, to see if it could help.

A “first-in-human” trial refers to the initial stage of testing a new drug or treatment in people. Before any medication or therapy can be used widely, it goes through rigorous testing in laboratories and animals to ensure safety and effectiveness.

The first-in-human trial is the critical step where researchers assess how safe the treatment is and what dosage might work without causing severe side effects. It involves a small number of carefully selected individuals who are closely monitored to understand how the treatment behaves in the human body, its potential side effects, and how the body processes it. This trial is a crucial starting point in the long process of developing new treatments for various diseases.

Zelenirstat’s Role in Mesothelioma Treatment

The good news is that most patients handled the treatment well, especially at lower doses. Some had minor side effects like upset stomachs, but nothing too serious. Even better, the treatment worked in the patients’ bodies and seemed to fight against cancer cells. Some patients had stable or smaller tumors after getting this treatment.

The trial showed that Zelenirstat is safe at 210 mg daily. But scientists are still studying more to see how well it works. These results are just the beginning, and scientists will keep looking to see if Zelenirstat can become a new way to treat cancers like mesothelioma.

In short, this first trial of Zelenirstat is a big deal, especially for people with cancers like mesothelioma. Even though more research is needed, these early results are really encouraging. They show that Zelenirstat could become a new way to fight mesothelioma and other challenging cancers, offering hope to many people in their fight against these tough diseases.


Sangha, Randeep, Rahima Jamal, Jennifer Spratlin, John Kuruvilla, Laurie H. Sehn, Michael Weickert, Luc Berthiaume, and John Robert Mackey. “A First-in-Human, Open-Label, Phase I Dose Escalation Trial of Daily Oral Nmt Inhibitor Zelenirstat in Patients with Relapsed/Refractory B-Cell Lymphomas and Advanced Solid Tumors.” Blood 142 (November 28, 2023): 6241. https://doi.org/10.1182/blood-2023-190058.


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