Search Results for: epithelioid

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    Study Lists Factors That Impact Mesothelioma Prognosis

    ByAlex Strauss

    Predicting survival in mesothelioma patients does not have to be complicated. A new Parisian study suggests that simple-to-measure factors such as patient age and the histological subtype of the mesothelioma can be highly accurate prognostic indicators. The study followed 170 patients diagnosed with malignant pleural mesothelioma between 2000 and 2010 at Saint Antoine Hospital in Paris. Patients in the study were all treated non-surgically. For each patient, a list of parameters was recorded including age, gender, tobacco use, asbestos exposure, type and duration of symptoms, BMI, C-reactive protein levels and white blood cell and platelet counts.  Inflammation of the pleura (pachypleuritis) was also noted, along with the type of diagnostic surgical procedure, histological subtype, the way in which pleurodesis was performed (for…

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    New ‘Calculator’ May Help Guide Mesothelioma Treatment

    ByAlex Strauss

    An NIH study claims to have found a better way to predict treatment response and survival in peritoneal mesothelioma patients. The information could be used to individualize treatment planning and determine which patients are most likely to benefit from aggressive therapies. Peritoneal mesothelioma is a rare type of cancer that arises in the thin membrane that lines the walls of the abdomen. Like all forms of mesothelioma, it is highly aggressive, spreading across the membrane quickly and metastasizing to other parts of the body. It is usually caused by exposure to asbestos sometime in the patient’s past. Treatment for peritoneal mesothelioma usually consists of surgery to remove as much of the tumor as possible (cytoreductive surgery) followed by a wash of heated…

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    Special Protein May Impact Mesothelioma Outcome

    ByAlex Strauss

    Mesothelioma patients whose cells express a protein called CD9 are likely to do better and live longer than those who don’t produce this special protein. That news comes out of a laboratory at Hiroshima University in Japan. CD9 is a cell surface glycoprotein involved in cell growth, adhesion and mobility. Its expression is associated with several other types of cancer. To measure the impact CD9 expression has on mesothelioma cells, a research team at the Institute of Biomedical and Health Sciences in Hiroshima first measured what happened to mesothelioma cells in the lab when CD9 expression was knocked down through gene manipulation. In those cell samples, knockdown of CD9 resulted in more mobility for the cancer cells. The team then examined…

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    Could Iron Removal Stave Off Mesothelioma?

    ByAlex Strauss

    Scientists have long known that exposure to asbestos can cause mesothelioma, but the jury is still out as to exactly why this happens. It is known that the shape of asbestos fibers makes them more likely to lodge deep in tissue, causing chronic irritation. But some have speculated that the high iron content of asbestos – particularly chrysotile asbestos – may also play a key role in triggering mesothelioma. A new study published in the Journal of Pathology appears to support the iron overload/mesothelioma connection.  Japanese scientists studied the effects of three commercially used types of asbestos – chrysotile, crocidolite and amosite – in laboratory rats. Of the three asbestos types, chrysotile brought on mesothelioma the fastest and iron overload…

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    Pleurodesis May Impact Mesothelioma Scan Results

    ByAlex Strauss

    Mesothelioma patients who undergo a procedure called talc pleurodesis (TP) for excess lung fluid may be harder to monitor with FDG-PET/CT scans afterward. Talc pleurodesis is a procedure used to manage pleura effusions, the build-up of fluid around the lungs that causes many of the most uncomfortable symptoms of malignant pleural mesothelioma. As a mesothelioma tumor spreads across the pleural lining, the body often produces fluid in response.  As this fluid fills up the pleural cavity between the mesothelial lining and the lungs it can cause pain and make it hard for the mesothelioma patient to breath. Draining the fluid and filling the space with medical-grade talc is one way to deal with the problem. But a new study suggests that…

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    “Encouraging” Mesothelioma Approach Combines Surgery and Light

    ByAlex Strauss

    A mesothelioma treatment approach that includes light-activated chemicals and a lung-sparing surgery is being called “safe” and “encouraging” by some of the nation’s top mesothelioma researchers. Radical pleurectomy and decortication (P/D) involves the removal of the thickened pleural membrane around the lungs and separation of the pleura from the chest wall. The goal is to allow the lung to expand more easily.  Because it is less likely to remove all of the mesothelioma cells than the more extensive approach known as Extrapleural Pneumonectomy (EPP), some doctors have only considered P/D for patients who would not tolerate lung removal. The debate among the world’s mesothelioma experts continues. But at the University of Pennsylvania, doctors are achieving notable success in treating mesothelioma with a…

  • MesoMark Falls Short for Early Mesothelioma Diagnosis

    ByAlex Strauss

    The Mesomark blood test for mesothelioma may miss the mark when it comes to diagnosing mesothelioma in its earliest stages. That is the conclusion of a large new study published in the Journal of Clinical Oncology.  The report was a meta-analysis of patients in 16 studies on the value of serum mesothelin as a marker for mesothelioma.  The studies included data on 4,491 patients, including 1,026 patients with malignant pleural mesothelioma and various control groups. All were measured for the level of mesothelin in their blood serum using the Mesomark test. Mesothelin is a protein present in the cells of the mesothelial membrane which surrounds the lungs and other internal organs. However, mesothelin is overexpressed in several types of tumors, including mesothelioma….

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    Cell Protein Linked to Mesothelioma Survival

    ByAlex Strauss

    A protein imbedded in the outer wall of their cells appears to have an impact on survival for mesothelioma patients. That’s the conclusion of researchers with a French mesothelioma study panel known as MESOPATH.  After examining 157 cases of malignant pleural mesothelioma, the group found that a protein called c-mesenchymal-epithelial transition factor (c-MET) could be correlated with survival in more than 75% of them. C-MET is one of many regulatory proteins found both inside and on the outer membrane of cells.  It is responsible for helping direct critical cell functions such as growth, survival, migration and invasion. But it has also been found to be overexpressed and mutated in a variety of malignancies. When the MESOPATH researchers tested mesothelioma cell samples,…

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    Vatalanib Not Effective as a ‘Single Agent’ for Mesothelioma

    ByAlex Strauss

    There has been a setback for doctors hoping the drug vatalanib would be a viable alternative to chemotherapy for mesothelioma patients. Scientists with the Cancer and Leukemia Group B (CALGB), a research team based at the University of California, have ruled out further study on the medication as a single agent (administered by itself) after a phase II trial found no significant survival benefit among mesothelioma patients. Vatalanib is an oral medicine classified as an anti-angiogenesis drug, designed to inhibit the formation of new blood vessels necessary to ‘feed’ a growing tumor. Although vatalanib has shown promise in the treatment of non-small cell lung cancer and has been compared to Avastin (bevacizumab), another anti-angiogenesis drug being tested for mesothelioma, the…

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    New Study Finds EPP Improves Mesothelioma Quality of Life

    ByAlex Strauss

    New research out of Italy casts another vote in favor of the controversial and radical surgical approach known as extrapleural pneumonectomy (EPP) for treating mesothelioma. Pleural mesothelioma occurs in the pleural membrane which separated the lungs from other internal organs. As the cancer spreads, it restricts the ability of the lungs to expand. Eventually, pleural mesothelioma can spread into the lungs themselves and other internal membranes. Extrapleural pneumonectomy attempts to prevent metastasis by removing the tissues most likely to be effected, including the lung lining, part of the pericardium (lining around the heart), a portion of the diaphragm, and the diseased lung. Because EPP is so radical and so risky (it carries a 60 percent complication rate), many of the…