Tag Archives: immune system

Immunotherapy for Peritoneal Mesothelioma: New Drug Trial Begin

immunotherapy for peritoneal mesothelioma

Researchers in Maryland and Missouri have started human testing of a new type of immunotherapy for peritoneal mesothelioma. If the human trial of this new CAR T-cell therapy goes as well as the laboratory tests, this could be good news for many people with asbestos cancer. CAR stands for chimeric antigen receptor. CAR T-cell therapy works by “reprogramming” a patient’s immune system to fight cancer cells. Tests show this therapy can work well for blood-based cancers like leukemia. But the results have not been as good for solid tumors like peritoneal mesothelioma. MaxCyte is the American company than makes the new drug. They are hoping that their approach to immunotherapy for peritoneal mesothelioma will be better. Preparing CAR T-cell Therapy … Continue reading Immunotherapy for Peritoneal Mesothelioma: New Drug Trial Begin »

Long Term Mesothelioma Survival with Immune System Activation

A small group of Australian mesothelioma patients have reportedly lived more than twice as long as expected with a combination of standard chemotherapy and immune system manipulation with the CD40 protein. The CD40 protein plays a role in a broad range of immune and inflammatory responses in the body. Studies in mice have found that activating CD40 with an activating antibody may work “synergistically” with chemotherapy drugs to fight cancer. To see whether CD40 activation could produce a similar response in human patients, researchers with the University of Western Australia and Sir Charles Gairdner Hospital in Perth recruited 15 malignant pleural mesothelioma patients in the early stages of the disease. The patients all received both standard chemotherapy (pemetrexed and cisplatin) … Continue reading Long Term Mesothelioma Survival with Immune System Activation »

Asbestos Causes Autoimmune Responses Connected to Mesothelioma

Mesothelioma and lung cancer are not the only risks associated with exposure to toxic minerals like asbestos. A study out of Idaho State University finds that asbestos also has a negative effect on the immune system. Once heavily used in construction and manufacturing, asbestos has been known for decades as the cause of mesothelioma, a rare but serious cancer. In recent years, another mineral called erionite has been suspected of causing mesothelioma. In the US, erionite has been found in gravel mined and used on roads, particularly in the state of North Dakota. Although the risks of mesothelioma from erionite and asbestos are understood, less is known about the immune system’s response to these minerals. In a report in Toxicology … Continue reading Asbestos Causes Autoimmune Responses Connected to Mesothelioma »

Asbestos Causes Autoimmine Responses Connected to Mesothelioma

Mesothelioma and lung cancer are not the only risks associated with exposure to toxic minerals like asbestos. A study out of Idaho State University finds that asbestos also has a negative effect on the immune system. Once heavily used in construction and manufacturing, asbestos has been known for decades as the cause of mesothelioma, a rare but serious cancer. In recent years, another mineral called erionite has been suspected of causing mesothelioma. In the US, erionite has been found in gravel mined and used on roads, particularly in the state of North Dakota. Although the risks of mesothelioma from erionite and asbestos are understood, less is known about the immune system’s response to these minerals.  In a report in Toxicology … Continue reading Asbestos Causes Autoimmine Responses Connected to Mesothelioma »

Mesothelioma Study Could Improve Immunotherapy

macrophage

Scientists have made an important discovery about a component of the immune system that could have an impact on mesothelioma, one of the rarest and most aggressive cancers. Although mesothelioma is rare, it claims about 2,500 lives in the U.S. annually. Scientists around the globe are searching for a method to keep this cancer from spreading across the membranes that surround the lungs or line the abdomen. As mesothelioma tumors on these membranes grow larger, the likelihood that the cancer will spread to the lungs or other internal organs increases. The immune system is designed to help stop the spread of invaders or out-of-control cancer cells. One immune cell, the Natural Killer or NK cell, is known to exert an anti-tumor effect … Continue reading Mesothelioma Study Could Improve Immunotherapy »

Mesothelioma ‘Triple Treatment’ May Jump Start Killer Cells

New mesothelioma research from Harvard University suggests that if one type of immunotherapy is effective against mesothelioma, three types might be even more effective. Immunotherapy involves manipulating the immune system to fight disease. Some types of cancer, including mesothelioma, take hold in the body in part by ‘shutting down’ the natural immunotoxins, or cell killers, that would normally attack them. Now, scientists are working with a number of molecules designed to jump start the immune system and help it recognize, target, and even ‘remember’ invading mesothelioma cancer cells. Using a mouse model of mesothelioma, the Harvard researchers investigated the roles of three factors effecting immunity: regulatory T-cells, intratumoural transforming growth factor (TGF)-â and cytotoxic T lymphocyte-associated antigen-4 (CTLA4). The researchers … Continue reading Mesothelioma ‘Triple Treatment’ May Jump Start Killer Cells »

Common Cold Virus – Uncommon Mesothelioma Treatment

Researchers at the University of Pennsylvania are fighting malignant mesothelioma with an unexpected tool – the cold virus. The approach fits into a category of treatment known as immunotherapy, which aims to harness the body’s own immune system to find and attack cancer cells. In the current study, Penn Medicine mesothelioma researchers, led by Steven Albelda, MD, and Daniel Sterman, MD, of the Pulmonary, Allergy, and Critical Care Division, injected mesothelioma patients with a modified form of the adenovirus – a virus normally associated with the common cold. The virus had been altered to express high levels of an immune system stimulant called Interferon-a, a protein that can boost the body’s ability to fight off viral infection. Nine mesothelioma patients … Continue reading Common Cold Virus – Uncommon Mesothelioma Treatment »

Immune System May Help Fight Mesothelioma

Proteins and toxins produced by the body’s own immune system could prove to be powerful weapons in the fight against malignant mesothelioma. Manipulating the immune system to fight cancer is known as immunotherapy. One type of immunotherapy is utilizing natural immunotoxins, or cell killers, produced by the white blood cells to attack tumors. Preliminary data shows that a protein produced by these cells called interleukin-4 or IL-4, may have potent cancer-fighting properties. Researchers with the Pacific Heart Lung & Blood Institute in California are planning studies to test the toxin’s value as a way to combat mesothelioma. Their first challenge will be to produce enough IL-4 to conduct tests. When enough of the immunotoxin can be synthesized according to FDA … Continue reading Immune System May Help Fight Mesothelioma »

Mesothelioma Vaccine Researched by UK Team

A team of Welsh researchers has begun studying a promising new immunotherapy treatment for mesothelioma. The researchers at Cardiff University and the Velindre Cancer Centre in Cardiff have partnered with Oxford, England-based Oxford BioMedica to study the company’s immunotherapy cancer vaccine called TroVax. Like other immunotherapy treatments, TroVax works by harnessing the power of the patient’s own immune system. The study’s lead researcher, Dr. Zsuzsanna Tabi of Cardiff University, recently discovered that mesothelioma tumor cells, like many other cancer cells, express a protein called 5T4. TroVax works by stimulating a patient’s body to produce an anti-5T4 immune response which would theoretically then target any tumor cells carrying the 5T4 protein. Although TroVax has been shown to produce an immune response … Continue reading Mesothelioma Vaccine Researched by UK Team »

Mesothelioma Therapies Benefit from Immune Approaches

Vaccines work by teaching the body’s immune system to recognize and destroy the germs that cause disease. That same principle is now being applied to vaccines against mesothelioma and other cancers. Vaccines and other immune-based therapies (immunotherapies) could be one of the new strategies to treat mesothelioma. This therapeutic approach may enhance the effectiveness of current treatments (including chemotherapy and radiation) while reducing side effects, according to a report published in the February/March issue of Cell Adhesion & Migration. Doctors have long realized that the immune system plays an important role in fighting cancer. Tumor associated proteins called tumor antigens are expressed on the surface of cancer cells. These are signals that could trigger the immune system to launch a … Continue reading Mesothelioma Therapies Benefit from Immune Approaches »