Tag Archives: inflammation

Systemic Inflammation Linked to Shorter Mesothelioma Survival

systemic inflammation

Mesothelioma patients whose bodies respond to the illness with systemic inflammation are less likely to survive. Chinese researchers have linked a measure of systemic inflammation called SII to shorter survival in people with pleural mesothelioma. The new study involved 97 people with confirmed malignant mesothelioma. It suggests that SII could be a simple, non-invasive way to determine mesothelioma prognosis. What is SII? SII stands for “systemic immune-inflammation index”. When a body is under stress, such as when it is fighting mesothelioma, the innate immune system kicks into action. Certain kinds of white blood cells and proteins are released. The result is systemic inflammation. SII can be determined with a blood test. The test measures the levels of white blood cells … Continue reading Systemic Inflammation Linked to Shorter Mesothelioma Survival »

Aspirin Slows Mesothelioma Growth by Fighting Inflammation

aspirin

A group of the world’s top mesothelioma researchers say aspirin may have a role to play in fighting malignant pleural mesothelioma. Aspirin (acetylsalicylic acid or ASA) is an that is known to help reduce the incidence and spread of certain inflammation-related cancers. Mesothelioma, a cancer that starts on the membrane around the lungs and tends to grow and spread quickly, is caused by an inflammatory response to asbestos fibers. That response is related to an inflammatory molecule called high-mobility group box 1 (HMGB1). Researchers at the University of Hawaii Cancer Center, along with colleagues at Cedars Sinai Medical Center in New York and two Italian hospitals theorized that a drug that fights inflammation might fight mesothelioma, too. Using mice infected with … Continue reading Aspirin Slows Mesothelioma Growth by Fighting Inflammation »

Inflammation Both “Friend and Foe” in Mesothelioma

Respiratory Disease

An immune system response that causes mesothelioma symptoms such as fever, fatigue, and weight loss may also be helpful to clinicians as a way to find and treat the disease. Scientists with The Asbestos Diseases Research Institute in Sydney, Australia make that case that both systemic inflammation (throughout the body) and at the site of a tumor – has long been associated with mesothelioma and other cancers. Inflammation results when the body attempts to address the imbalances of cancer by producing more of certain immune system cells. Some inflammatory markers, such as CD+8 T-cells and C-reactive protein, have been linked to better prognosis in mesothelioma. Other inflammatory markers, such as certain macrophages and a high neutrophil-to-lymphocyte ratio, can signal the … Continue reading Inflammation Both “Friend and Foe” in Mesothelioma »

Mesothelioma May Be Caused by Inflammation According to New Study

New National Cancer Institute-funded research at the University of Hawaii may help pave the way for finding and stopping the growth of mesothelioma tumor cells. Mesothelioma is caused by exposure to asbestos fibers. The new study, published in the current issue of the Proceedings of the National Academy of Sciences, shows how tiny shards of asbestos kill some cells and turn others into malignant cancer cells. In collaboration with researchers at New York University, the University of Chicago, the University of Pittsburgh, San Raffaele University of Milano and the Imperial College in London, the U of H team found that cells killed by asbestos fibers through a process called necrosis release a molecule called high-mobility group box 1 protein (HMGB1). … Continue reading Mesothelioma May Be Caused by Inflammation According to New Study »