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Body Swelling and Joint Pain in Malignant Pleural Mesothelioma

Body Swelling and Joint Pain in Malignant Pleural MesotheliomaThe diagnosis of malignant pleural mesothelioma often includes widespread body inflammation. Inflammation and body swelling occur when white blood cells try to protect against infection. Symptoms of inflammation are often redness, swelling, and joint pain or stiffness.

Oncologists have studied the relationship between swelling and cancer for 150 years. New research was recently published in the scientific journal Lung Cancer.

French medical oncologists believe that patients with more body swelling may have shorter survival. This suggests that body swelling may play a big role in malignant pleural mesothelioma.

Body Swelling to Predict a Developing Mesothelioma Diagnosis

Prediction of diagnosis is important for malignant pleural mesothelioma patients. The sooner a patient can be diagnosed, the better their outcomes.

Oncologists suggest that widespread body swelling, along with other symptoms, may predict mesothelioma. A new study looked at simple clinical factors connected with swelling.

A combination of these factors may be used to predict developing disease.

Measuring Body Swelling and Inflammation Factors in the Clinic

Data was reported from a single hospital. They followed a 20-year cohort of mesothelioma patients. Swelling and pain-related numbers and clinical scores were tested as predictive indicators.

There were three clinical scores, or clinical tests, used to measure swelling. While these tests have long names, each is a proven method in measuring patient swelling.

First, the “Mean Neutrophil to Lymphocyte Ratio” measures swelling in a blood sample.

The second is the “Systemic Inflammation Index.” This is yet another way for clinicians to measure body swelling. This method is a promising predictor for other various malignant tumors.

The “Advanced Lung cancer inflammation Index” is the final tool. This is an easy-to-calculate tool to assess ongoing swelling in cancer patients. High widespread body swelling is a predictive marker of poor cancer outcomes.

Together these three tests allow oncologists to measure a patient’s inflammation. This combined measurement provides more data to understand the state of the disease. And it allows the oncologist to make a treatment plan.


A malignant pleural mesothelioma diagnosis is strongly influenced by widespread body swelling and joint pain. Patients with higher clinical inflammation scores have shorter survival. This data shows the major role played by swelling in mesothelioma.


Fournel, Ludovic, Thomas Charrier, Maxime Huriet, Amedeo Iaffaldano, Audrey Lupo, Diane Damotte, Jennifer Arrondeau, and Marco Alifano. “Prognostic impact of inflammation in malignant pleural mesothelioma: a large-scale analysis of consecutive patients.” Lung Cancer (2022). https://doi.org/10.1016/j.lungcan.2022.03.014

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