Tag Archives: mesothelioma therapy

Japanese Doctors Test Potential New Target for Mesothelioma Therapy

. Mesothelioma is a fast-growing and currently incurable cancer that occurs most often in people who have been exposed to the mineral asbestos. It grows on the linings around the lungs or other organs making surgery and targeted radiotherapy especially difficult. Current chemotherapy drugs typically do not improve survival by more than a few months and researchers around the world continue to search for a way to attack mesothelioma at the cellular level. Now, a new study out of Japan suggests that ganglioside GM2, a surface glycolipid that is overexpressed in a number of cancer types including multiple myeloma, neuroblastoma, and mesothelioma, may offer a way to do that. Glycolipids provide energy and serve as markers for cellular recognition. Oncologists … Continue reading Japanese Doctors Test Potential New Target for Mesothelioma Therapy »

Finding May Strengthen New Mesothelioma Therapy

NIH scientists believe they may have found a way to help ensure the effectiveness of a new mesothelioma drug called SS1P. SS1P is currently in clinical trials for malignant pleural mesothelioma, a rare but virulent cancer caused by asbestos inhalation. SS1P works by targeting mesothelin, an antigen expressed on the surface of several types of human cancer cells. In mesothelioma cells, mesothelin is frequently ‘shed’ and ends up in the fluid around the lungs, where it is often used to help make a diagnosis. Unfortunately, this ‘shedding’ reduces the effectiveness of SS1P and other therapies that attempt to use mesothelin to find and target mesothelioma cells with anti-cancer drugs. Like the shed mesothelin, the anti-cancer drugs can simply end up … Continue reading Finding May Strengthen New Mesothelioma Therapy »

Potential Mesothelioma Therapy in a Spice

The major component in the spice turmeric may help treat drug resistant pleural mesothelioma. Researchers at Wayne State University in Detroit have been studying the effects of the compound, known as curcumin, on mesothelioma cells in the laboratory and in animal subjects. Their research suggests that curcumin has the power to attack mesothelioma from several angles. Pleural mesothelioma is an asbestos-related malignancy of the mesothelial tissue surrounding the lungs. It is aggressive and notoriously difficult to treat. The platinum-based chemotherapy drugs often used as a first-line treatment for mesothelioma may be ineffective if the patient has a strain of the disease that is resistant to them. So far, there is no proven alternative drug therapy for these patients. Now, the … Continue reading Potential Mesothelioma Therapy in a Spice »

Mesothelioma Virus-Based Therapy is Promising

A potential new therapy for mesothelioma could come in the form of a cancer-targeting virus that selectively destroys cancer cells while sparing healthy cells. Triggering that virus to express the antiviral protein, interferon-beta, could further enhance the immune response against the cancer, and reduce the risk of treatment side effects, according to a study of mice published in the October 1 issue of Cancer Research. The viruses used in the study are called oncolytic viruses, and their potential lies in their ability to specifically target cancer cells without harming healthy cells. “The viruses that we use have a preferential tropism for cancer cells over normal cells. That is, they replicate in mesothelioma cells much more potently than they do in … Continue reading Mesothelioma Virus-Based Therapy is Promising »

Study Reveals Mesothelioma Therapy Risks and Benefits

Treating mesothelioma aggressively with a combination of surgery, chemotherapy, and radiation (trimodality therapy, or TMT) might improve survival in a small number of patients, but it may not be the best option for those with more advanced cancer. Imaging tests alone can’t identify the most appropriate candidates for surgery, and as a result, many patients may be unnecessarily undergoing a risky procedure that won’t improve their odds of survival, according to a recent study in the ANZ Journal of Surgery. David Sugarbaker, MD, of the Brigham and Women’s Hospital in Boston has reported positive results from combining extrapleural pneumonectomy (EPP—surgery to remove the diseased lung, as well as the diaphragm and the membrane covering the heart and lung), followed by chemotherapy and radiation. … Continue reading Study Reveals Mesothelioma Therapy Risks and Benefits »

Promising New Target for Mesothelioma Therapy

Mesothelin, a protein found on the surface of cells, may be a promising new target for treating mesothelioma, as well as several other types of cancers, according to a recent study in the journal, Molecular Cancer Therapeutics. This protein might also help doctors diagnose certain cancers. The reason why mesothelin has captured researchers’ attention as a potential therapeutic target has to do with the way it is distributed in the body. In healthy people, mesothelin is only found in small amounts in cells lining the lungs, abdominal cavity, and heart. However, this protein is produced in higher amounts by mesothelioma, ovarian, and pancreatic cancer cells. To attack these cancers, researchers are looking at using specialized antibodies (a type of immune … Continue reading Promising New Target for Mesothelioma Therapy »