Tag Archives: peritoneal mesothelioma

Spread of Peritoneal Mesothelioma Slows with Apatinib

spread of peritoneal mesothelioma

An investigational drug called apatinib may help stop the growth and spread of peritoneal mesothelioma. Chinese researchers recently tested the VEGF inhibitor on mice infected with human mesothelioma.  They found that the spread of peritoneal mesothelioma slowed way down in the presence of apatinib. The drug worked in the lab and in live mice with few serious side effects. If larger experiments confirm apatinib’s effectiveness, the next step could be trials in human mesothelioma patients.  Apatinib Blocks Blood Vessel Formation Apatinib is also known as Rivoceranib. It keeps cancer cells from using the protein VEGF. VEGF (vascular endothelial growth factor) allows tumors to spawn new blood vessels. A rich supply of fresh blood fuels the growth and spread of peritoneal … Continue reading Spread of Peritoneal Mesothelioma Slows with Apatinib »

Peritoneal Mesothelioma Survival Not Shortened by Organ Resection

peritoneal mesothelioma survival

A new study finds that organ resection during CRS/HIPEC surgery does not shorten peritoneal mesothelioma survival and may even help prolong it.  The new research included 174 peritoneal mesothelioma patients from cancer centers across the country. These patients had cytoreductive surgery followed by heated intraperitoneal chemotherapy (CRS/HIPEC).  About half of the patients also had at least one organ removed to help prevent mesothelioma recurrence. The goal of the new study was to determine what impact, if any, this practice has on peritoneal mesothelioma survival. The answer appears to be, not much.  CRS/HIPEC and Peritoneal Mesothelioma Survival About 20 percent of mesothelioma patients have the peritoneal variety. This type of mesothelioma occurs on the lining of the abdomen and can easily … Continue reading Peritoneal Mesothelioma Survival Not Shortened by Organ Resection »

Long Term Peritoneal Mesothelioma Survival with NIPEC

Long Term Peritoneal Mesothelioma Survival

A new report suggests that long term peritoneal mesothelioma survival may be possible with a treatment called NIPEC and the drug paclitaxel.  NIPEC stands for normothermic intraperitoneal chemotherapy. It is similar to the heated chemotherapy that many peritoneal mesothelioma patients now get. But NIPEC is delivered through a catheter over time and at room temperature.  The new article details the long term peritoneal mesothelioma survival of six patients on NIPEC with paclitaxel. It comes from one the nation’s leading experts in this form of mesothelioma, Paul Sugarbaker, MD.  Even though the sample size is small, Dr. Sugarbaker says the results are impressive enough to warrant further study.  HIPEC and Mesothelioma Treatment Peritoneal mesothelioma accounts for about 20 percent of mesothelioma … Continue reading Long Term Peritoneal Mesothelioma Survival with NIPEC »

Surgery for Peritoneal Mesothelioma Could Be Limited During Pandemic

Surgery for peritoneal mesothelioma

It may be harder this year for patients who need it to get surgery for peritoneal mesothelioma.  An international group called RENAPE keeps track of peritoneal cancers like mesothelioma. The group advises doctors on the best treatment practices. The group is advising hospitals to tighten the criteria for who can get surgery for peritoneal mesothelioma during the pandemic.  “The Covid-19 pandemic is profoundly changing the organization of healthcare access,” say French doctors writing about the RENAPE recommendations. “This is particularly so for peritoneal neoplastic diseases, for which curative treatment mobilizes substantial personnel, operating room and intensive care resources.” Mesothelioma Treatment Options Mesothelioma is a rare cancer associated with asbestos exposure. About a fifth of all mesothelioma cases are the peritoneal … Continue reading Surgery for Peritoneal Mesothelioma Could Be Limited During Pandemic »

Radical Surgery for Peritoneal Mesothelioma Boosts Survival

radical surgery for peritoneal mesothelioma

Patients who have radical surgery for peritoneal mesothelioma live longer than those who have non-surgical treatments.  That is the conclusion of a team of Virginia researchers. The study is based on peritoneal mesothelioma cases in the National Cancer Database. It spans more than a decade and includes over 2,000 patients.  Not everyone is a candidate for radical surgery for peritoneal mesothelioma. But the research shows that those who have surgery live an average of five times longer than those who do not.  Surgical Treatment of Peritoneal Mesothelioma Peritoneal mesothelioma is sometimes called diffuse malignant peritoneal mesothelioma. It is an aggressive cancer in the abdomen. It grows on the membrane around organs. Because mesothelioma tumors lie so close to these organs, … Continue reading Radical Surgery for Peritoneal Mesothelioma Boosts Survival »

Invasiveness of Peritoneal Mesothelioma: MRI Beats CT for Assessment

invasvieness of peritoneal mesothelioma

New research shows MRI beats CT when it comes to measuring the invasiveness of peritoneal mesothelioma. Scientists from several of the top US cancer centers ran the study. It included nearly 500 mesothelioma patients and appears in the journal Clinical Colorectal Cancer.  The study shows that the invasiveness of peritoneal mesothelioma is more visible on MRI than it is on CT. The news could make a difference in how doctors plan peritoneal mesothelioma treatment.  Peritoneal Cancer Index and Mesothelioma Peritoneal mesothelioma cancer grows on the peritoneal membrane lining the abdomen. Like all forms of mesothelioma, it usually comes from exposure to asbestos. Peritoneal mesothelioma accounts for about a fifth of all mesothelioma cases.  Doctors assess the invasiveness of peritoneal mesothelioma … Continue reading Invasiveness of Peritoneal Mesothelioma: MRI Beats CT for Assessment »

Peritoneal Mesothelioma Surgery with HIPEC Can Trigger Blood Cell Problems

peritoneal mesothelioma surgery with HIPEC

More than half of patients who have peritoneal mesothelioma surgery with HIPEC develop problems with their blood cells afterward. That’s the finding of a team of cancer researchers from Singapore.  The group analyzed 15 years worth of data on peritoneal mesothelioma surgery outcomes. They found that, even though the procedure saves lives, it can be risky.  Older patients and those who had prior chemotherapy were most likely to develop hematological toxicities after peritoneal mesothelioma surgery.  Hematological Toxicities and Mesothelioma Treatment Hematological toxicities are problems with the cells that make up the blood. This can include white blood cells, red blood cells, platelets, and proteins involved in bleeding and clotting.  Several drugs that kill mesothelioma cells can cause blood cell problems. … Continue reading Peritoneal Mesothelioma Surgery with HIPEC Can Trigger Blood Cell Problems »

Repeated Mesothelioma Surgeries Credited with Japanese Man’s Survival

repeated mesothelioma surgeries

Can repeated mesothelioma surgeries extend peritoneal mesothelioma survival? A new case report out of Japan suggests the answer may be yes.  The article recounts the case of a patient with peritoneal mesothelioma. Each time surgeons removed a mesothelioma tumor, a new one would occur in a different location.  The man had four separate mesothelioma surgeries over the course of five years.  Repeated mesothelioma surgeries are not the norm. But this treatment approach may be the reason for the man’s unusually long mesothelioma survival.  Surgical Treatment of Peritoneal Mesothelioma Peritoneal mesothelioma accounts for about 20 percent of mesothelioma cases in the US each year. It occurs on the membrane that surrounds the abdominal organs. Because it sits so close to these … Continue reading Repeated Mesothelioma Surgeries Credited with Japanese Man’s Survival »

Signs of Peritoneal Mesothelioma After Radiotherapy

signs of peritoneal mesothelioma after radiotherapy

Japanese researchers are reminding doctors to watch for signs of peritoneal mesothelioma in people who have undergone past radiotherapy.  Many cancer patients undergo radiotherapy. Radiation disrupts the DNA inside cancer cells. This can help keep these malignant cells from replicating and spreading.  But radiation treatment also has a downside. It can cause cellular changes in healthy cells, too. This can cause side effects right away, or decades later.  As more people have radiation and survive, scientists at the Shinshu University School of Medicine say more of them could develop radiation-related mesothelioma later in life. But the signs of peritoneal mesothelioma years after radiation are easy to miss. Peritoneal Mesothelioma Case Study The new report is based on the case of … Continue reading Signs of Peritoneal Mesothelioma After Radiotherapy »

Risk for Peritoneal Mesothelioma Keeps Rising Decades After Exposure

risk for peritoneal mesothelioma

Pleural mesothelioma risk may level off over several decades, but the risk for peritoneal mesothelioma never goes down. That is the conclusion of researchers at Italy’s University of Eastern Piedmont. It is based on data from more than 50,000 asbestos-exposed Italian workers.   More than 40 years after asbestos exposure, the workers’ risk for peritoneal mesothelioma continued to rise. Calculating Mesothelioma Rates Over Time Asbestos is the primary cause of all types of malignant mesothelioma. Even short-term asbestos exposure raises the risk for peritoneal mesothelioma and pleural mesothelioma. Peritoneal mesothelioma occurs in the lining of the abdomen. Pleural mesothelioma tumors start on the lining around the lungs.  If asbestos fibers are inhaled or swallowed, they embed themselves in these linings. This … Continue reading Risk for Peritoneal Mesothelioma Keeps Rising Decades After Exposure »