Tag Archives: virotherapy

Combination Mesothelioma Therapy Begins Pivotal Trial

mesothelioma treatment combination

A combination mesothelioma therapy that showed promise in early trials is finally being studied on a larger scale. The power-packed chemo-immuno-gene therapy known as TR002 has the potential to change the outlook for thousands of malignant mesothelioma patients. A small trial of the combination mesothelioma therapy in 2016 produced “significantly higher” mesothelioma survival rates than most patients are told to expect. Drug company Trizell announced last month that the combination will now be tested on 300 patients at sites in the US, Europe, Australia and Russia. Combination Mesothelioma Therapy Starts with Gene Therapy TR002 is an investigational gene therapy for mesothelioma patients who have failed first-line chemotherapy. This combination mesothelioma therapy is based on the human interferon-alpha 2b gene. The … Continue reading Combination Mesothelioma Therapy Begins Pivotal Trial »

Virotherapy for Mesothelioma Can Be More Effective

virotherapy for mesothelioma

Hong Kong researchers may have found a way to get around one of the biggest challenges of virotherapy for mesothelioma. Virotherapy uses a modified virus to deliver medicine or genetic information into the body. Modified viruses are useful because they can be “programmed” to seek out cancer cells. But modified viruses do not always behave the way scientists hope they will. One problem with some virotherapy for mesothelioma is that it can block the natural immune response. The body naturally fights malignant mesothelioma by releasing white blood cells called CTLs (T lymphocytes). But MVTT virotherapy can prevent the release of CTLs, even while it attacks the tumor. “Although MVTT [a type of virotherapy] leads to regression of established mesothelioma dose-dependently, … Continue reading Virotherapy for Mesothelioma Can Be More Effective »

Measles May Help Fight Mesothelioma

A new mesothelioma clinical trial being conducted at the Mayo Clinic uses an altered version of the measles virus to combat the deadly cancer. The potential of the measles virus to kill cancers like mesothelioma was noticed many years ago, before vaccination curtailed the spread of measles. In several cases, cancer patients who contracted natural measles experienced shrinkage of their tumors. Today, advanced molecular science has made it possible to insert a new gene into the measles virus that can further increase its specificity and potency against mesothelioma tumor cells. Because malignant pleural mesothelioma (the most common type) arises on the mesothelial membrane around the lungs, Mayo Clinic researchers administer the altered measles virus directly into the pleural space, between the lungs … Continue reading Measles May Help Fight Mesothelioma »

Mesothelioma and Virotherapy

A recently published study* suggests that virotherapy may be a viable treatment option for mesothelioma, as well as for other cancers. Virotherapy is the use of biotechnology to convert viruses into cancer-fighting agents by reprogramming viruses to only attack cancerous cells An agent of change for patients with “no real treatment alternatives” “Normally, viruses replicate to increase their number, and by virtue of that process, healthy cells are killed,” explains David T. Curiel, MD, PhD, director of the Division of Human Gene Therapy at the University of Alabama at Birmingham. “Virotherapy is about engineering viruses so that they replicate only in tumor cells – and kill only tumor cells.” In order to engineer an effective virus, scientists must first understand … Continue reading Mesothelioma and Virotherapy »