Scientists think they now have a better understanding of why most women with mesothelioma live longer than men. Malignant mesothelioma is four times more common in men than in women. But many studies show that women with mesothelioma do better than men after treatment. Researchers with The International Mesothelioma Program at Brigham and Women’s Hospital in Boston say the difference is in the genes. Their new study focused on the potentially protective role of estrogen signaling genes in female patients. The RERG Gene and Mesothelioma Survival In the latest study, researchers analyzed genetic data and survival in groups of mesothelioma patients. The groups included both men and women with mesothelioma. The goal was to determine what aspect of the women’s … Continue reading Estrogen Signaling Genes May be Secret to Survival for Women with Mesothelioma
Female mesothelioma patients are less likely to have surgery and other aggressive treatments than male patients are, but they still tend to live longer. That’s according to a nine-year study of nearly 19,000 pleural mesothelioma patients. Researchers at the University of Pennsylvania’s Perelman School of Medicine led the study. The team used the National Cancer Database to identify pleural mesothelioma cases diagnosed between 2004 and 2013. The study included more than four thousand female mesothelioma patients. The conclusion is that there are serious disparities in the way doctors treat men and women with malignant mesothelioma. Gender Differences in Mesothelioma Incidence Exposure to asbestos is the primary cause of malignant mesothelioma. Although it can affect either gender, most mesothelioma patients are … Continue reading Study Highlights Treatment Disparities in Female Mesothelioma Patients
Italian researchers say women who live around an asbestos plant or with one of its workers may be at special risk for mesothelioma from the combination of familial and environmental asbestos exposure. The research appears in a new issue of the Annals of Work Exposures and Health. Scientists have long known about the link between asbestos on worker’s clothes and mesothelioma among the women who wash those clothes. But the new report shows that some of these women face an even greater cumulative risk because of environmental asbestos exposure. Bringing the Mesothelioma Risk Home Traditionally, most jobs with the potential for asbestos exposure have been in male-dominated industries. These include industries like construction, shipbuilding, plumbing, electrical work, and asbestos mining … Continue reading Familial and Environmental Asbestos Exposure Raise Mesothelioma Risk in Women
A major study of mesothelioma in women finds that women tend to contract the disease earlier in life than men do. The analysis included 354 cases of malignant mesothelioma from a database of more than 2,800. While the average age for pleural mesothelioma diagnosis is 72, the average age for women to be diagnosed with any type of mesothelioma was just 60. It could mean that the latency period for mesothelioma is shorter for women than it is in men. It could also mean that women are more attuned to mesothelioma symptoms and recognize the disease sooner. Mesothelioma’s Long Latency The latency period is the time between exposure to a cancer-causing agent and the occurrence of cancer. Mesothelioma has one … Continue reading Mesothelioma in Women: Study Reveals Diagnostic Trends
A new study of National Cancer Institute data aims to better understand who survives mesothelioma and why. Malignant mesothelioma is a highly aggressive cancer of internal membranes. Very few people diagnosed with mesothelioma live longer than 18 months. But researchers around the world are working to change those odds. One important step is to look at the characteristics of those who live longest with the asbestos cancer. NCI Data Shows Who Survives Mesothelioma Scientists at Mount Sinai Medical Center in New York turned to the National Cancer Institute database to get a better picture of who survives mesothelioma. The database contains information reported by mesothelioma doctors from around the country. It includes information about the ages, gender, lifestyle, mesothelioma type, … Continue reading Who Survives Mesothelioma and Why?
There’s evidence that female sex hormones may help explain the better survival rates in women with peritoneal mesothelioma. The news could open the door for a new way to treat the disease. Peritoneal mesothelioma is a rare form of mesothelioma that attacks the membrane around abdominal organs. Like most forms of mesothelioma, it is believed to be caused by asbestos and carries a poor prognosis. In addition to being less likely to contract mesothelioma than their male counterparts, women are also less likely to die from it quickly. Now, researchers at St. George Hospital in Sydney, Australia think they may know why. The team analyzed data on 52 consecutive peritoneal mesothelioma patients treated with cytoreductive surgery and heated intraperitoneal chemotherapy … Continue reading Sex Hormones May Account for Better Mesothelioma Survival in Women
Although the study did find an elevated number of mesothelioma cases among plant workers, the biggest mesothelioma burden was among their spouses and other women who lived in the region. Almost half of the mesothelioma cases linked to the factory could be attributed to environmental, rather than occupational, exposure. Researchers with the Department of Preventive Medicine in Milan and the National Heart & Lung Institute at Imperial College London calculated mesothelioma incidence connected to an asbestos cement factory that operated in Broni, Italy from 1932 to 1993. Their goal was to compare the percentage of cases among the workers themselves with the number of cases among their families and those who simply lived near the plant. Data was collected between … Continue reading Are Women More Vulnerable to Mesothelioma from Environmental Asbestos?
A new study of more than 14,000 American mesothelioma patients finds that women are three times more likely to survive mesothelioma than men are. Researchers from the North Shore/Long Island Jewish Health System-Hofstra School of Medicine and Mount Sinai Health System in New York studied all pathologically confirmed mesothelioma cases in the national Surveillance, Epidemiology and End Results (SEER) database between 1973 and 2009. Patients were analyzed by age, year of diagnosis, race, stage, treatments, gender and other factors. The team then used the data to assess the association between the various prognostic factors and survival. Of the 14,228 malignant pleural mesothelioma cases analyzed, 22% occurred in women. These women tended to be diagnosed at around the same cancer stage … Continue reading Women Much More Likely to Survive Mesothelioma than Men
Women with epithelial mesothelioma who receive induction chemotherapy prior to surgery have the highest chance of benefitting from the radical surgical approach known as extrapleural pneumonectomy (EPP). That is the conclusion reached by a team of thoracic surgeons from nine Italian medical centers. The team collected outcome and survival data on 518 malignant pleural mesothelioma patients who underwent lung-removing extrapleural pneumonectomy (EPP) surgery between 2000 and 2010. Most of the patients in the study (84.4%) had the epithelial variety of mesothelioma, the most common subtype of pleural mesothelioma. A little over half of the study subjects had chemotherapy prior to their surgery. Known as induction or neoadjuvant chemotherapy, the goal of this treatment is to shrink mesothelioma tumors to improve … Continue reading Radical Surgery Outcomes Better in Women
Women with diffuse malignant peritoneal mesothelioma have a better chance of success with surgery and chemotherapy than their male counterparts. That is the conclusion of researchers at the Baird Institute for Applied Heart and Lung Surgical Research in Sydney, Australia. Using the records of 294 peritoneal mesothelioma patients treated at multiple institutions in the past two decades, the researchers set out to measure the impact of gender on overall survival after treatment. Peritoneal mesothelioma is a type of mesothelioma that spreads quickly across the mesothelial lining of the abdomen. Asbestos exposure is its only known cause. Because of the aggressive nature of the disease, mesothelioma is typically treated using a multi-modal approach. The subjects of the Australian study had all been … Continue reading Outlook Better for Women with Peritoneal Mesothelioma