New Discoveries in Mesothelioma Treatment: The Role of Vaccines

ByHolly Zink
New Discoveries in Mesothelioma Treatment: The Role of Vaccines

Vaccines can strengthen our immune system against various diseases. This success is partially due to antibody responses and invigorating T-cell immunity. This is a critical component in fighting infections and cancers.

Mesothelioma is a cancer with formidable resistance to treatment. A new study looks at a new vaccine regimen for mesothelioma. The study comes from the University of Hong Kong.

Augmenting Mesothelioma Defense

Research shows the importance of T-cell responses for improving clinical outcomes in mesothelioma. Scientists have been working to create a perfect vaccine strategy. It would strengthen protective T-cell immunity against viral infections and delay cancer progression.

During the COVID-19 pandemic, vaccines were developed quickly. They reduce viral transmission and reduce severe illness. However, treatment also has to increase mucosal immunity in the upper respiratory tract to stop viral transmission.

A new vaccine regimen was created to solve this problem. Significantly, this regimen also created a high lung-resident memory T cells frequency. This suggests an effective means of mesothelioma treatment in the future.

Progressing Mesothelioma Vaccines Beyond Antibodies

A new study extended this new vaccine regimen to mesothelioma with good success. T-cell responses and lung memory T-cell frequencies improved mesothelioma survival rates.

The DNA/LAIV vaccine regimen may be a transformative approach. It has been effective in protecting mice from lung metastasis. And other models have upheld this theory.

These groundbreaking findings show the significance of optimizing prime-boost vaccine strategies to strengthen mucosal T-cell immunity. This new combination presents a promising future for fighting mesothelioma metastasis.

Source:

Xu, Haoran. “Function of Vaccine-Induced Lung Tissue Resident Memory T Cells in Lung Metastasis and COVID-19 Protection,” 2023. http://hub.hku.hk/handle/10722/335992.

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