|

Caution in Mesothelioma Pain Medicine Use

ByHolly Zink
Caution in Mesothelioma Pain Medicine Use

A newly published case study shows how important it is for doctors to be careful when giving pain medicine to patients with mesothelioma.

Malignant pleural mesothelioma (MPM) is an aggressive cancer that grows in the lining of the lungs. It is caused by exposure to asbestos. MPM is also the most common form of mesothelioma. It accounts for over 90,000 deaths per year around the world.

Mesothelioma Diagnosis and Symptoms

It takes a very long time to diagnose mesothelioma. Usually, it takes almost 40 years after asbestos exposure to reach a diagnosis. Prognosis is poor with an average survival of 8 to 14 months from diagnosis. The 5-year survival rate is currently 10%.

The symptoms of MPM can include shortness of breath due to fluid around the lung, chest pain, cough, and fatigue.

The standard treatments for malignant pleural mesothelioma (MPM) are chemotherapy, radiation, and surgery. While these treatments can help to improve a patient’s health, they can also cause pain and discomfort.

Since MPM itself and the necessary treatments can cause so much pain for patients, pain medicine is an important part of any treatment plan. Proper pain treatment can improve a person’s quality of life during a difficult diagnosis. One common drug for pain is morphine, but it can be dangerous if people are given too much.

Treating Mesothelioma Pain

In this case, a patient with malignant pleural mesothelioma had a lot of tumors in their abdomen and problems with their liver and kidneys. They were given morphine and a sedative called benzodiazepine to help with the pain. But their doctor ended up giving too much morphine and the patient became unresponsive.

Luckily, doctors were able to stabilize the patient and ultimately send him home.

Morphine is widely used in hospitals to treat pain, especially for cancer patients. This case study is an important reminder that doctors and patients need to be careful with pain medications, even with common ones like morphine.

MPM patients who are given morphine should be closely monitored by doctors to avoid overdoses.

Source

Zhao C, Bai J, Jia S, et al. Morphine poisoning in a patient with malignant peritoneal mesothelioma: A case report. Exp Ther Med. 2023;25(5):197. Published 2023 Mar 17. doi:10.3892/etm.2023.11896. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119626/

Similar Posts

Doctors Describe "Concrete Therapeutic Approach" for Mesothelioma
| |

Doctors Describe "Concrete Therapeutic Approach" for Mesothelioma

ByAlex Strauss

A team of medical researchers in Italy have achieved what they are calling “excellent” tumor control and survival results in malignant pleural mesothelioma patients using a combination of surgery, chemotherapy, and radiotherapy. Caused by exposure to asbestos, mesothelioma typically spreads quickly across the lung-encasing membrane called the pleura. There is no known cure but treatments are improving. In the current prospective study, 20 malignant pleural mesothelioma patients underwent radical pleurectomy/decortication followed by high doses of radiation. After surgeons removed as much of the visible mesothelioma tumor and surrounding tissue as possible, patients received 50Gy of radiation to the effected side of their chest, delivered in 25 fractions. Regions of particular concern for mesothelioma regrowth got an extra radiation “boost” to…

Does Radiotherapy Reduce Mesothelioma Pain?
| |

Does Radiotherapy Reduce Mesothelioma Pain?

ByAlex Strauss

A new study says there is not enough evidence to support the use of radiotherapy for the treatment of pain associated with malignant pleural mesothelioma. Researchers at the University of Edinburgh in Scotland reviewed a range of past studies on mesothelioma pain and radiotherapy by searching databases that date back as far as 1974. To be eligible to be included in their review, the study had to focus on malignant pleural mesothelioma and radiotherapy given “with the intent of improving pain”. The study also had to report doses and fractionation of the radiotherapy and how the pain responded. In all, the researchers found eight studies on mesothelioma pain and radiotherapy that met the criteria. Two of the studies were prospective…

Teacher’s Diagnosis Highlights Mesothelioma Risk in Schools
|

Teacher’s Diagnosis Highlights Mesothelioma Risk in Schools

ByAlex Strauss

A recent mesothelioma diagnosis in the UK once again dramatically highlights the fact that even a small amount of asbestos can be deadly. Sixty-three-year-old school teacher Marion Potts of Brockenhurst died of mesothelioma in a Southampton hospital in June. According to an article in The Mirror, the Coroner recorded a verdict of “death from an industrial disease” after hearing evidence last week that Potts actually saw asbestos dust being released when she pinned work on the classroom walls. Most recently, Potts was head of the English department at Romsey School in Hampshire until her retirement two years ago. Mesothelioma is a growing threat among school teachers, administrators, maintenance workers, and even students in British schools. A government report released last…

Radiotherapy for Mesothelioma: Better But Still Limited
| |

Radiotherapy for Mesothelioma: Better But Still Limited

ByAlex Strauss

A form of highly-targeted radiation therapy for mesothelioma is better than it used to be, but is still risky. That is the message of a recent article on intensity-modulated radiation therapy (IMRT) in Seminars in Thoracic and Cardiovascular Surgery. Author Kenneth E. Rosenzweig, MD, a Radiation Oncologist with Mount Sinai Hospital in New York, reviewed recent studies on IMRT and mesothelioma. He concludes that, while the “troubling toxicity” associated with IMRT when it was first introduced has not been entirely eliminated, the fact that clinicians now have more experience with it is making a positive difference for mesothelioma patients. Before targeted therapies like IMRT were available, high-dose radiation was not usually a feasible option for mesothelioma since the irregular shape…

A Second-Line Option for Mesothelioma?
| |

A Second-Line Option for Mesothelioma?

ByAlex Strauss

Although survival was not significantly extended, the chemotherapy drug vinorelbine might be a treatment option for mesothelioma patients whose cancer has returned after first-line chemotherapy with pemetrexed. A new study on vinorelbine as a second-line treatment finds that the drug is “moderately active” in mesothelioma patients who were initially treated with pemetrexed-based chemotherapy. Pemetrexed (Alimta), along with a platinum-based drug like cisplatin, is the primary first-line drug therapy for mesothelioma. But vinorelbine is gaining attention as a possible option for mesothelioma, in part because it is available in a less expensive generic form. In “Vinorelbine in pemetrexed-pretreated patients with malignant pleural mesothelioma”, the Italian authors detail the results of their study on 59 patients with unresectable pleural mesothelioma.  These patients…

Repeat HIPEC Improves Mesothelioma Survival
| |

Repeat HIPEC Improves Mesothelioma Survival

ByAlex Strauss

If one cytoreductive surgery and HIPEC procedure for mesothelioma is good, subsequent treatments may be even better. That is the central message of research conducted at the Moffitt Cancer Center in Florida. The study’s aim was to assess overall survival among peritoneal mesothelioma patients who had not just one, but two or more rounds of heated intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery. The cytoreduction/HIPEC approach has become popular for peritoneal mesothelioma, a treatment-resistant cancer of abdominal membranes caused by asbestos. Cytoreductive surgery involves removing as much of the mesothelioma tumor as possible from the abdomen. Because the shape and spreading pattern of mesothelioma tumors make complete cytoreduction difficult, the surgery is often followed by a rinse with a heated solution…