|

Mesothelioma Risk is Rarely Outlived

ByAlex Strauss

1912051_doctors2

If you have been exposed to asbestos, whether at work or in the home, you may never outlive your risk of developing malignant mesothelioma. That unsettling finding comes from a recently-published medical stud conducted by researchers in Australia and Italy.

Mesothelioma has a particularly long latency period, meaning it is not uncommon for it to take decades for this aggressive cancer to develop. To determine if asbestos-exposed individuals can ever consider themselves out of danger, the researchers compiled and analyzed data from eight separate previous studies on the relationship between asbestos exposure and mesothelioma development. Six of the studies focused on people with occupational exposure to the deadly toxin and the remaining two included people with residential asbestos exposure.

Among the more than 22,000 asbestos-exposed individuals included in the studies, 707 eventually developed pleural mesothelioma (around the lungs) while another 155 people develop peritoneal (in the abdomen) mesothelioma. One-hundred and sixty-five of the pleural mesothelioma cases and 32 of the peritoneal cases occurred in women. The median duration of exposure among people who developed pleural mesothelioma was 3.75 years and it took a median of 38.4 years for mesothelioma symptoms to develop.

But, while the risk of developing pleural mesothelioma appeared to decline somewhat after 45 years post-exposure, the risk of peritoneal mesothelioma continued to rise even after 50+ years. Lead author Dr. Alison Reid, Associate Professor in the School of Public Health at Australia’s Curtin University, concludes, “While the rate of increase appears to start to level out after 40 to 50 years, no one survives long enough for the excess risk to disappear.”

This is disturbing news for tens of thousands of people around the world who have lived or worked around asbestos, a once-popular component of many building materials. While there is still no proven way to predict mesothelioma development, some studies have suggested that regular monitoring by a physician and periodic CT scans may increase the chances of catching the cancer earlier, when treatment is likely to be most effective.

Reid, A et al, “Mesothelioma risk after 40 years since first exposure to asbestos: a pooled analysis”, May 9, 2014, Thorax, Epub head of print

Similar Posts

  • | |

    Mesothelioma survivor Paul Kraus, alive and well 19 years after writing “Surviving Mesothelioma and Other Cancers

    ByAlex Strauss

    Paul Kraus is considered the longest documented mesothelioma survivor in the world. He was diagnosed in 1997 with mesothelioma so widespread that he was given little hope of survival. Not willing to give up, he worked with a team of doctors to create his own tailored treatment protocol. This protocol included dramatic life style change, experimental therapies, dietary changes, mind-body medicine, and other modalities. Paul was fortunate. The protocol he and his doctors created helped him keep the mesothelioma in check. His book “Surviving Mesothelioma and Other Cancers: A Patient’s Guide” details his cancer voyage, the decisions he made, and his philosophies about health and healing. This book is now the best-selling mesothelioma book in the world and has inspired…

  • | |

    Doctors Describe "Concrete Therapeutic Approach" for Mesothelioma

    ByAlex Strauss

    A team of medical researchers in Italy have achieved what they are calling “excellent” tumor control and survival results in malignant pleural mesothelioma patients using a combination of surgery, chemotherapy, and radiotherapy. Caused by exposure to asbestos, mesothelioma typically spreads quickly across the lung-encasing membrane called the pleura. There is no known cure but treatments are improving. In the current prospective study, 20 malignant pleural mesothelioma patients underwent radical pleurectomy/decortication followed by high doses of radiation. After surgeons removed as much of the visible mesothelioma tumor and surrounding tissue as possible, patients received 50Gy of radiation to the effected side of their chest, delivered in 25 fractions. Regions of particular concern for mesothelioma regrowth got an extra radiation “boost” to…

  • |

    Mesothelioma Still Rising Despite Ban in Ireland

    ByAlex Strauss

    A study in Ireland confirms that it can take many years for a ban on asbestos to have a measurable impact on a country’s rates of malignant mesothelioma. Mesothelioma is the most serious of a list of diseases – including lung cancer, pleural plaques, asbestosis, and others – linked with exposure to asbestos dust. Affecting the linings around the lungs and other organs, mesothelioma is often resistant to most cancer treatments and may be fatal within a year of diagnosis. According to the International Ban Asbestos Secretariat, Ireland is one of 55 countries that have enacted some type of asbestos ban. However, although Ireland banned asbestos in 2000, a new study published in Cancer Epidemiology shows that incidence of the…

  • | |

    Does Radiotherapy Reduce Mesothelioma Pain?

    ByAlex Strauss

    A new study says there is not enough evidence to support the use of radiotherapy for the treatment of pain associated with malignant pleural mesothelioma. Researchers at the University of Edinburgh in Scotland reviewed a range of past studies on mesothelioma pain and radiotherapy by searching databases that date back as far as 1974. To be eligible to be included in their review, the study had to focus on malignant pleural mesothelioma and radiotherapy given “with the intent of improving pain”. The study also had to report doses and fractionation of the radiotherapy and how the pain responded. In all, the researchers found eight studies on mesothelioma pain and radiotherapy that met the criteria. Two of the studies were prospective…

  • |

    Website Aims to Protect Homeowners from Mesothelioma

    ByAlex Strauss

    Australia’s Cancer Council is trying to educate home renovators about their risk for mesothelioma with a new e-learning course. Australia has one of the highest per capita rates of mesothelioma in the world, largely because of several asbestos mining operations that were once located there. Although asbestos has been banned from building products in Australia since 1989, asbestos-linked diseases like mesothelioma, lung cancer, and asbestosis continue to pose a serious health concern. While mesothelioma has traditionally occurred among people exposed to asbestos on the job, Australia is now bracing for another “wave” of mesothelioma victims among homeowners who encounter asbestos while doing their own renovation projects. Cancer Council Australia has launched “kNOw asbestos in your home” in an effort to…

  • |

    Ape Virus Shrinks Mesothelioma Tumors in Lab

    ByAlex Strauss

    A virus that causes leukemia in gibbon apes may have the power to help fight malignant mesothelioma in people. Gibbon ape leukemia virus (GALV) has been tested for years as a viral vector, a carrier of therapeutic genetic information, in the treatment of various human illnesses, including cancer. A new study in Japan compared GALV with a leukemia virus derived from mice to see which carrier communicated most efficiently with mesothelioma cells. While both types of viruses replicated in most of the mesothelioma cell lines tested, the mouse-derived virus was not effective in a mesothelioma cell line called ACC-MESO-1. In this cell line, only the GALV spread efficiently both in culture and in mice that had been given human mesothelioma…