Tag Archives: combination treatment

New Drug Targeting Fibrosis may Help Mesothelioma Patients

Targeting Fibrosis in Mesothelioma has Therapeutic Benefits

Targeting fibrosis has therapeutic benefits in mesothelioma. Most drugs have limited effects in difficult-to-treat cancers such as mesothelioma. Often this is because not enough of the drug can get into the tumor to generate an anti-tumor effect. Fibrosis is a common element of mesothelioma. It causes the area around the cancer to stiffen. Fibrosis acts as a barrier, stopping drugs from getting into the cancer tumor. This limits the immune system’s ability to detect and access the tumor to kill it. A new study is looking at how a family of proteins called lysyl oxidases can help solve this problem. These proteins are associated with fibrosis in many cancers, including mesothelioma. Oncologists targeting fibrosis and this protein family may improve … Continue reading New Drug Targeting Fibrosis may Help Mesothelioma Patients »

Combination Treatment Fights Mesothelioma “Synergistically”

Cancer researchers in Italy are working on a way to use the body’s own cancer-fighting tools to help boost the effectiveness of chemotherapy for mesothelioma. They are concentrating their efforts on a protein called TNF-related apoptosis-inducing ligand, also known as TRAIL. TRAIL is a cytokine that is produced by most normal tissue cells but causes apoptosis (programmed cell death) in tumor cells. TRAIL is one of the ways the body helps keeps cancers like mesothelioma from gaining a foothold. Recently, doctors at the University of Padua ran a test combining a form of TRAIL made from human cells with standard chemotherapy drugs to help fight malignant pleural mesothelioma. The lab-produced TRAIL, called dulanermin, was administered along with pemetrexed and carboplatin … Continue reading Combination Treatment Fights Mesothelioma “Synergistically” »