New research suggests an inherited mutation on the BLM gene increases susceptibility to deadly malignant mesothelioma. The research comes from the University of Hawaii, one of the world’s top locations for mesothelioma research. Researcher Michele Carbone and his team sequenced the DNA of 155 mesothelioma patients. They found that people who are missing one BLM gene are much more likely to contract mesothelioma – especially if they are exposed to asbestos. If people know they have the BLM gene mutation, they could potentially cut their risk for mesothelioma by being especially mindful of asbestos exposure. Genetic Susceptibility to Mesothelioma Asbestos exposure is the primary cause of malignant mesothelioma. Some people who live or work around asbestos develop mesothelioma years later. … Continue reading BLM Gene Mutation Increases Mesothelioma Risk, Study Finds
New research on gene editing technology for cancer suggests that it could be the key to one day curing intractable cancers like malignant mesothelioma. Researchers at Tel Aviv University have used a technology called CRISPR to dramatically extend the lives of mice with some of the most serious kinds of cancer. Gene editing technology alters the genes of cancer cells so they cannot replicate. The Israeli team found a way to make it target cancer cells. It could be the breakthrough that many mesothelioma doctors have been hoping for. Genes and Mesothelioma The genetic material inside a person’s cells determines how those cells will behave. Genes encode for proteins which give signals to cells. Gene editing technology aims to change … Continue reading Gene Editing Technology May Hold the Key to Curing Mesothelioma
A mutation of the BAP1 gene may not be the only reason mesothelioma can sometimes run in families. A more complex genetic picture may also help explain why some asbestos-exposed workers get the disease and some do not. Exposure to asbestos is the number one cause of malignant mesothelioma, an aggressive cancer that starts on the membranes that surround internal organs. But only a tiny percentage of people exposed to asbestos – many of whom were construction workers, asbestos plant employees, or veterans – ever contract mesothelioma. Past studies have explained the disparity, in part, by showing that a mutation on the BAP1 gene appears to make some people more susceptible to the damaging effects of asbestos. But a new … Continue reading Could Other Gene Mutations Be Behind Mesothelioma?
Exposure to crocidolite asbestos triggers enhanced DNA damage that can turn cells cancerous, according to a study published online September 25 in the American Journal of Respiratory Cell and Molecular Biology. The discovery might one day lead to a new method of screening people who have been exposed to asbestos and are at risk for mesothelioma and other cancers. The connection between asbestos and cancers such as mesothelioma has been well documented. Because decades can pass before asbestos-related cancers are diagnosed, and patients with mesothelioma survive an average of just a few years, it is crucial to identify signs of increased cancer risk as early as possible. One way might be to look for DNA damage in patients who have been exposed … Continue reading Mesothelioma and Other Cancers Caused by Asbestos Through DNA Damage