A mutation of the BAP1 gene may not be the only reason mesothelioma can sometimes run in families. A more complex genetic picture may also help explain why some asbestos-exposed workers get the disease and some do not. Exposure to asbestos is the number one cause of malignant mesothelioma, an aggressive cancer that starts on the membranes that surround internal organs. But only a tiny percentage of people exposed to asbestos – many of whom were construction workers, asbestos plant employees, or veterans – ever contract mesothelioma. Past studies have explained the disparity, in part, by showing that a mutation on the BAP1 gene appears to make some people more susceptible to the damaging effects of asbestos. But a new … Continue reading Could Other Gene Mutations Be Behind Mesothelioma?
Exposure to crocidolite asbestos triggers enhanced DNA damage that can turn cells cancerous, according to a study published online September 25 in the American Journal of Respiratory Cell and Molecular Biology. The discovery might one day lead to a new method of screening people who have been exposed to asbestos and are at risk for mesothelioma and other cancers. The connection between asbestos and cancers such as mesothelioma has been well documented. Because decades can pass before asbestos-related cancers are diagnosed, and patients with mesothelioma survive an average of just a few years, it is crucial to identify signs of increased cancer risk as early as possible. One way might be to look for DNA damage in patients who have been exposed … Continue reading Mesothelioma and Other Cancers Caused by Asbestos Through DNA Damage