The Role of Asbestos in Mesothelioma Development in Nordic Countries
A new study of pleural mesothelioma in Nordic countries highlights the critical role of asbestos in mesothelioma development. Asbestos is the primary cause of mesothelioma around the world. There are many statistics on the incidence of mesothelioma in countries that use asbestos. But there is not much information on mesothelioma incidence, mortality, and survival prior to the popularity of asbestos. This makes it difficult to quantify the influence of asbestos in mesothelioma development. Researchers from the Czech Republic, Germany, Finland and China compiled the new information using the NORDCAN cancer database. The database includes statistics on mesothelioma in Denmark, Finland, Norway, and Sweden dating back as far as the 1940s. Their analysis, published in BMC Cancer, is a sobering reminder … Continue reading The Role of Asbestos in Mesothelioma Development in Nordic Countries
The Link Between Pleural Plaques and Mesothelioma
Fibrous thickening of the lung lining known as pleural plaques are a good indicator of asbestos exposure but they don’t necessarily mean that a person will development mesothelioma. That is the finding of a risk analysis released by a Princeton, New Jersey-based consulting firm. The firm studied the medical literature on pleural plaques to better understand the relationship between this common asbestos exposure side effect and the development of mesothelioma, the most deadly disease associated with asbestos. Pleural plaques typically develop two or three decades after asbestos exposure. They can grow on either the outer (parietal) pleura or the inner (visceral) pleura. While they can make breathing uncomfortable as they calcify over time, pleural plaques are not cancerous and have … Continue reading The Link Between Pleural Plaques and Mesothelioma
Multi-Center Study Reveals “Genomic Basis” of Mesothelioma
Doctors with the Broad Institute of Harvard and MIT, the University of Hawaii Cancer Center, and the Departments of Cardiothoracic Surgery and Genome Technology at New York’s Langone Medical Center, have identified four specific genes they believe are directly linked to mesothelioma development. Scientists have long known that asbestos in the tissue can trigger genetic mutations that lead to mesothelioma. But, while past studies have focused on small sets of genes and have provided a limited view of these mutations, this new study is the first to analyze the entire gene for all possible genetic alterations. The new study involved whole exome sequencing – or a complete analysis of the DNA – on 22 malignant pleural mesothelioma patients. “Integrative analysis … Continue reading Multi-Center Study Reveals “Genomic Basis” of Mesothelioma
Mesothelioma Risk is Rarely Outlived
If you have been exposed to asbestos, whether at work or in the home, you may never outlive your risk of developing malignant mesothelioma. That unsettling finding comes from a recently-published medical stud conducted by researchers in Australia and Italy. Mesothelioma has a particularly long latency period, meaning it is not uncommon for it to take decades for this aggressive cancer to develop. To determine if asbestos-exposed individuals can ever consider themselves out of danger, the researchers compiled and analyzed data from eight separate previous studies on the relationship between asbestos exposure and mesothelioma development. Six of the studies focused on people with occupational exposure to the deadly toxin and the remaining two included people with residential asbestos exposure. Among … Continue reading Mesothelioma Risk is Rarely Outlived
Researchers Get Inside Mesothelioma Development
When asbestos fibers get inside the body, they trigger a number of biological pathways that can eventually lead to the development of mesothelioma and other lung cancers. Learning how these pathways are formed can help researchers develop new treatment approaches to combat these deadly cancers, according to a study recently published in the American Journal of Respiratory Cell and Molecular Biology. Researchers have long known that on-the-job exposure to asbestos can lead to mesothelioma, as well as other cancers. Now they are trying to determine exactly what cascade of events asbestos triggers that causes cells to turn cancerous. Understanding the biological processes behind mesothelioma development is critical to finding new therapies for this currently incurable disease. Whether a person develops … Continue reading Researchers Get Inside Mesothelioma Development
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