| | | | | | | |

Second Surgery May Prolong Mesothelioma Survival

ByAlex Strauss

2313161_surgeon4There is new evidence that surgery may be the most effective type of second-line treatment for malignant pleural mesothelioma.

First-line therapies for malignant mesothelioma include surgery, chemotherapy, radiation and experimental approaches such as immunotherapy.

However, the waters become murkier after mesothelioma recurrence. There is no widely-accepted second-line treatment protocol for mesothelioma.

Facts About Mesothelioma Relapse

A new study conducted at University Hospital Zurich in Switzerland reveals some important facts about the way in which mesothelioma typically recurs after treatment.

After examining the cases of 136 mesothelioma patients who underwent presurgical chemotherapy and extrapleural pneumonectomy surgery between 1999 and 2013, the team found that:

  • Pleural mesothelioma usually recurs at the site of the original tumor. Seventy-nine (74%) of the 106 recurrences happened either at the original site only or at the original site and in another spot, as well
  • Mesothelioma patients were less likely to experience local recurrence of their malignant mesothelioma if they had radiation after surgery, although this did not affect mesothelioma survival
  • People whose mesothelioma tumors recurred only at the original spot survived a median of 5 months longer than the average for the group as a whole

Mesothelioma Survival After Second Surgery

A total of 78 of the 106 mesothelioma patients whose tumors came back after treatment elected to undergo a second-line therapy. More than half (48) had chemotherapy, 9 had radiotherapy, 10 had surgery, and 11 had a combination of these treatments.

Of these treatments, second line surgery appeared to have the greatest impact on post-recurrence mesothelioma survival (PRS).

“The median PRS after surgery was significantly longer than that of patients receiving chemo-, radio-, or chemo-radiotherapy,” writes lead author Arthur Kostron, MD. Dr. Kostron and his colleagues conclude that second-line mesothelioma treatment, especially with surgery, can offer “good long-term outcome for selected patients.”

Source:

Kostron, A, et al, “Relapse pattern and second-line treatment following multimodality treatment for malignant pleural mesothelioma”, November 20, 2015, European Journal of Cardiothoracic Surgery, Epub ahead of print

Similar Posts

Mesothelioma survivor Paul Kraus, alive and well 19 years after writing “Surviving Mesothelioma and Other Cancers
| |

Mesothelioma survivor Paul Kraus, alive and well 19 years after writing “Surviving Mesothelioma and Other Cancers

ByAlex Strauss

Paul Kraus is considered the longest documented mesothelioma survivor in the world. He was diagnosed in 1997 with mesothelioma so widespread that he was given little hope of survival. Not willing to give up, he worked with a team of doctors to create his own tailored treatment protocol. This protocol included dramatic life style change, experimental therapies, dietary changes, mind-body medicine, and other modalities. Paul was fortunate. The protocol he and his doctors created helped him keep the mesothelioma in check. His book “Surviving Mesothelioma and Other Cancers: A Patient’s Guide” details his cancer voyage, the decisions he made, and his philosophies about health and healing. This book is now the best-selling mesothelioma book in the world and has inspired…

Doctors Describe "Concrete Therapeutic Approach" for Mesothelioma
| |

Doctors Describe "Concrete Therapeutic Approach" for Mesothelioma

ByAlex Strauss

A team of medical researchers in Italy have achieved what they are calling “excellent” tumor control and survival results in malignant pleural mesothelioma patients using a combination of surgery, chemotherapy, and radiotherapy. Caused by exposure to asbestos, mesothelioma typically spreads quickly across the lung-encasing membrane called the pleura. There is no known cure but treatments are improving. In the current prospective study, 20 malignant pleural mesothelioma patients underwent radical pleurectomy/decortication followed by high doses of radiation. After surgeons removed as much of the visible mesothelioma tumor and surrounding tissue as possible, patients received 50Gy of radiation to the effected side of their chest, delivered in 25 fractions. Regions of particular concern for mesothelioma regrowth got an extra radiation “boost” to…

Mesothelioma Still Rising Despite Ban in Ireland
|

Mesothelioma Still Rising Despite Ban in Ireland

ByAlex Strauss

A study in Ireland confirms that it can take many years for a ban on asbestos to have a measurable impact on a country’s rates of malignant mesothelioma. Mesothelioma is the most serious of a list of diseases – including lung cancer, pleural plaques, asbestosis, and others – linked with exposure to asbestos dust. Affecting the linings around the lungs and other organs, mesothelioma is often resistant to most cancer treatments and may be fatal within a year of diagnosis. According to the International Ban Asbestos Secretariat, Ireland is one of 55 countries that have enacted some type of asbestos ban. However, although Ireland banned asbestos in 2000, a new study published in Cancer Epidemiology shows that incidence of the…

Does Radiotherapy Reduce Mesothelioma Pain?
| |

Does Radiotherapy Reduce Mesothelioma Pain?

ByAlex Strauss

A new study says there is not enough evidence to support the use of radiotherapy for the treatment of pain associated with malignant pleural mesothelioma. Researchers at the University of Edinburgh in Scotland reviewed a range of past studies on mesothelioma pain and radiotherapy by searching databases that date back as far as 1974. To be eligible to be included in their review, the study had to focus on malignant pleural mesothelioma and radiotherapy given “with the intent of improving pain”. The study also had to report doses and fractionation of the radiotherapy and how the pain responded. In all, the researchers found eight studies on mesothelioma pain and radiotherapy that met the criteria. Two of the studies were prospective…

Website Aims to Protect Homeowners from Mesothelioma
|

Website Aims to Protect Homeowners from Mesothelioma

ByAlex Strauss

Australia’s Cancer Council is trying to educate home renovators about their risk for mesothelioma with a new e-learning course. Australia has one of the highest per capita rates of mesothelioma in the world, largely because of several asbestos mining operations that were once located there. Although asbestos has been banned from building products in Australia since 1989, asbestos-linked diseases like mesothelioma, lung cancer, and asbestosis continue to pose a serious health concern. While mesothelioma has traditionally occurred among people exposed to asbestos on the job, Australia is now bracing for another “wave” of mesothelioma victims among homeowners who encounter asbestos while doing their own renovation projects. Cancer Council Australia has launched “kNOw asbestos in your home” in an effort to…

Ape Virus Shrinks Mesothelioma Tumors in Lab
|

Ape Virus Shrinks Mesothelioma Tumors in Lab

ByAlex Strauss

A virus that causes leukemia in gibbon apes may have the power to help fight malignant mesothelioma in people. Gibbon ape leukemia virus (GALV) has been tested for years as a viral vector, a carrier of therapeutic genetic information, in the treatment of various human illnesses, including cancer. A new study in Japan compared GALV with a leukemia virus derived from mice to see which carrier communicated most efficiently with mesothelioma cells. While both types of viruses replicated in most of the mesothelioma cell lines tested, the mouse-derived virus was not effective in a mesothelioma cell line called ACC-MESO-1. In this cell line, only the GALV spread efficiently both in culture and in mice that had been given human mesothelioma…