Tag Archives: genetics

Gene Targeting Slows Aggressive Form of Pleural Mesothelioma

Aggressive Form of Pleural Mesothelioma

Scientists in Vienna are developing a new treatment for a particularly aggressive form of pleural mesothelioma.  This form of mesothelioma occurs in people with a genetic mutation. The mutation produces signals that fuel tumor growth. These patients typically have an even worse prognosis than other mesothelioma patients.  But the Austrian team came up with a way to block activation of the mutated gene. If the gene does not send its signal, this aggressive form of pleural mesothelioma may grow more slowly.  Aggression Fueled by Telomerase Malignant mesothelioma is one of the most aggressive kinds of cancer. It starts on the membranes around organs and can quickly spread to other parts of the body. By the time most people notice symptoms, … Continue reading Gene Targeting Slows Aggressive Form of Pleural Mesothelioma »

CRISPR Gene Editing Technique and the Future of Mesothelioma Treatment

CRISPR gene editing tehcnique

The powerful CRISPR gene editing technique might have a role to play in the future of mesothelioma treatment. CRISPR is a method for altering certain genes to help fight disease. This week, scientists at the University of Pennsylvania released data from the first study of CRISPR in US cancer patients.  It was only a safety study, but the results are promising. They could have wide-ranging implications for patients fighting aggressive cancers like malignant mesothelioma.  Modifying Genes To Help Fight Cancer The CRISPR gene editing technique is a simplified version of the method bacteria cells use to defend themselves against viruses. This antiviral defense system is called CRISPR-Cas9. The new Penn Medicine study involved just three cancer patients. Two of the … Continue reading CRISPR Gene Editing Technique and the Future of Mesothelioma Treatment »

Spotting the BAP1 Gene Mutation in Mesothelioma Patients

BAP1 gene mutation

New guidelines may make it easier to tell which mesothelioma patients contracted the disease because of a BAP1 gene mutation. The knowledge could have an impact on mesothelioma treatment planning. BAP1 stands for BRCA associated protein-1. People who have an inherited BAP1 gene mutation face a higher risk for several conditions, including malignant mesothelioma.  Very few mesothelioma patients have the mutation and gene testing is not routine. So researchers at a top US cancer center have developed a set of screening criteria. The criteria may help predict which mesothelioma patients could benefit from genetic testing. Testing for the Altered Gene Mesothelioma is just one of the conditions associated with the inherited BAP1 gene mutation. People with this condition are also … Continue reading Spotting the BAP1 Gene Mutation in Mesothelioma Patients »

Study Highlights How Genes Impact Mesothelioma Survival

Genes impact mesothelioma survival

A new National Cancer Institute study shines a light on some of the ways genes impact mesothelioma survival. It could have important implications for mesothelioma treatment. The study was led by prominent mesothelioma researcher Raffit Hassan, MD. It focused on genetic mutations that may make certain mesothelioma patients more sensitive to chemotherapy. Genes, Genotype, and Mesothelioma Treatment A mesothelioma patient’s unique collection of genes, including genetic mutations, is known as their genotype. Genes impact mesothelioma survival in a variety of ways. Tumor suppressor genes are supposed to help keep tumors from forming. People with mutations on these genes may be more likely to get malignant mesothelioma. Other genes influence the cancer’s ability to “hide” from detection by the immune system. … Continue reading Study Highlights How Genes Impact Mesothelioma Survival »

Genetics-Based Cancer Treatment Could Mean New Hope for Mesothelioma

genetic-based cancer treatment for targeted mesothelioma therapy

The FDA has approved a new genetics-based cancer treatment that could open the door for more targeted mesothelioma therapy. The drug is called larotrectinib. The drug company Bayer sells it under the brand name Vitrakvi. Larotrectinib is unique because it is not specific to any one type of cancer. Instead, larotrectinib is based on a patient’s genetic biomarkers. It is the first drug of its kind to gain approval by the FDA. What is a Genetics-Based Cancer Treatment? A genetics-based cancer treatment is a drug that targets certain genetic mutations. Doctors find these mutations by testing for biomarkers. One mutation could cause breast cancer, colon cancer, or even pleural mesothelioma. Some kinds of mutations are connected to only one type … Continue reading Genetics-Based Cancer Treatment Could Mean New Hope for Mesothelioma »