Understanding Mesothelioma: Clues from Calretinin for Patients

Understanding Mesothelioma: Clues from Calretinin for Patients

ByHolly Zink

Malignant mesothelioma is a tough cancer caused by asbestos. It’s hard to treat because it grows quickly and is tough to beat. A recent study took a close look at a protein called calretinin. Scientists wanted to see if it could help predict how long someone might live with this cancer and how well they might respond to treatment. A Possible Game-Changer in Mesothelioma Care The study looked at 265 patients with this mesothelioma. They checked how much calretinin was in their blood and looked at the genes linked to how calretinin works. Scientists used tests to measure calretinin and found differences in genes among patients. Then they checked if these things were connected to how long patients lived or…

Understanding Mesothelioma: Clues in the Blood
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Understanding Mesothelioma: Clues in the Blood

ByHolly Zink

Pleural mesothelioma is a tough cancer caused by asbestos. It’s hard to treat because it is rare and grows differently in people. A recent study tried to find clues that could help doctors figure out how to treat mesothelioma better. Helping Treat Mesothelioma In this study, they looked at 98 people with pleural mesothelioma. Researchers checked the patient’s blood for a few different factors. They wanted to see if a patient’s blood could tell how long someone might live with this cancer. They also wanted to use a patient’s blood to predict which treatment may work best for them. Researchers also learned from what treatments had worked for these patients in the past. Some treatments like surgery or multi-modal treatment…

Covering Mesothelioma Changes in Western Australia: Understanding Asbestos Connections

Covering Mesothelioma Changes in Western Australia: Understanding Asbestos Connections

ByHolly Zink

Back in 1984, Australia took a big step by partly banning asbestos. But worries remained about people being around asbestos in the environment and outside of work. A new study looked at mesothelioma changes in Western Australia over 60 years since they started keeping track. Mesothelioma Over 60 Years Experts checked every case of mesothelioma reported to the Western Australia Cancer Registry. They looked at who got it, how they were exposed to asbestos, and how long it took for the cancer to show up after being around asbestos. They found over 2,700 mesothelioma cases, mostly in men (84.7%). People usually get diagnosed around 70 years old. And it took about 47 years from being near asbestos to get diagnosed….

Understanding Survival in Asbestos-Linked Cancers: How Asbestos Exposure Matters

Understanding Survival in Asbestos-Linked Cancers: How Asbestos Exposure Matters

ByHolly Zink

Malignant mesothelioma is a cancer caused by asbestos, and it’s tough to beat. But, some people with this cancer live longer than expected. A recent study in a science journal called Toxics looked at patients with mesothelioma and asbestos-related lung cancer. All of them had been around asbestos between 2009 and 2021. The Hidden Impact of Asbestos The study found some interesting things. People who got exposed to asbestos at work not only lived for a shorter time but also had lower chances of surviving longer. This compares to those who were around asbestos in the environment. They found that the longer someone worked with asbestos and the closer they were to it, the less time they lived with both…

Improving Survival in Epithelioid Mesothelioma: Following Treatment Guidelines

Improving Survival in Epithelioid Mesothelioma: Following Treatment Guidelines

ByHolly Zink

When doctors treat epithelioid mesothelioma, they use a mix of treatments. Treatment guidelines often include chemotherapy and surgery. But, a new study looked at whether patients were getting these recommended treatments and how it affected how long they lived. The Role of Guidelines in Prolonging Life A recent study checked data from an extensive database of mesothelioma patients between 2004 and 2016. They wanted to see if doctors followed the guidelines and if that affected how well patients did. They found something surprising. Only about 19% of 3,534 patients got the treatments that doctors usually recommend. Also, certain patients were more likely to get the recommended treatment. These were younger patients or those with insurance. Also, people living in wealthier…

New Ways to Fight Mesothelioma: Stronger Treatment with Immunotherapy Mix

New Ways to Fight Mesothelioma: Stronger Treatment with Immunotherapy Mix

ByHolly Zink

In the battle against mesothelioma, scientists are trying out new methods that use the body’s own defenses. A recent study in Cancer Science explored a treatment called combination immunotherapy. It uses special medicines that help the immune system and has worked well for other cancers. Using Immunotherapy to Fight Mesothelioma Researchers are studying a protein called podoplanin (PDPN) in malignant pleural mesothelioma. This protein could help diagnose the cancer and be a target for treatment. Scientists made a special antibody to attack PDPN, aiming to kill cancer cells. But they weren’t sure how these antibodies worked with other immune cells or with the medicines used in immunotherapy. In a new study, scientists made new and improved antibodies to better attack…

New Discoveries in Mesothelioma Treatment: The Role of Vaccines

New Discoveries in Mesothelioma Treatment: The Role of Vaccines

ByHolly Zink

Vaccines can strengthen our immune system against various diseases. This success is partially due to antibody responses and invigorating T-cell immunity. This is a critical component in fighting infections and cancers. Mesothelioma is a cancer with formidable resistance to treatment. A new study looks at a new vaccine regimen for mesothelioma. The study comes from the University of Hong Kong. Augmenting Mesothelioma Defense Research shows the importance of T-cell responses for improving clinical outcomes in mesothelioma. Scientists have been working to create a perfect vaccine strategy. It would strengthen protective T-cell immunity against viral infections and delay cancer progression. During the COVID-19 pandemic, vaccines were developed quickly. They reduce viral transmission and reduce severe illness. However, treatment also has to…

Understanding Malignant Pleural Mesothelioma: What You Need to Know
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Understanding Malignant Pleural Mesothelioma: What You Need to Know

ByHolly Zink

Malignant pleural mesothelioma is a rare cancer caused by asbestos. It starts in the lining of the lungs and can cause symptoms similar to tuberculosis. A new article published in Respiratory Medicine provides a modern, comprehensive clinical overview of malignant pleural mesothelioma. The article provides an in-depth summary of everything you need to know. Navigating Malignant Pleural Mesothelioma Malignant pleural mesothelioma is not very common. In fact, only around 30,000 new cases were reported worldwide in 2020. This kind of cancer tends to affect older patients more, especially those over 40, and is more common in men. Malignant pleural mesothelioma is caused by exposure to asbestos, a material used in old buildings. The way malignant pleural mesothelioma grows in the…

Unlocking Cancer’s Weakness: How Scientists Are Targeting Mesothelin

Unlocking Cancer’s Weakness: How Scientists Are Targeting Mesothelin

ByHolly Zink

When it comes to fighting cancer, scientists have been working hard to find better ways to help patients. One exciting area they’re exploring is something called CAR-T therapy, which targets specific proteins found on cancer cells. One of these proteins, called mesothelin, is found in different kinds of cancer like mesothelioma, ovarian, lung cancer, and some types of leukemia. But using CAR-T therapy against mesothelin has been tricky. The treatment sometimes gets tired out, and other proteins in the body can stop it from working well. To fix these problems, scientists have come up with a new way to make CAR-T therapy work better against mesothelin in cancer. Game-Changing Journey to Success First off, they made a special kind of…

The Power of First-in-Human Trials: A Glimpse into Zelenirstat’s Impact on Mesothelioma
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The Power of First-in-Human Trials: A Glimpse into Zelenirstat’s Impact on Mesothelioma

ByHolly Zink

The journey towards a breakthrough cancer treatment often begins with groundbreaking trials. Zelenirstat is a cutting-edge drug currently under study. It has shown promise in its first-ever trial involving mesothelioma patients. These are significant first steps in paving the way for potential new treatments. A First-In-Human Trial Scientists are exploring a new treatment, Zelenirstat for tough cancers like mesothelioma. They tested this treatment on 21 patients with various cancers. This was in a special trial called a “first-in-human” trial. They gave different doses of Zelenirstat, starting from 20 mg to 280 mg every day, to see if it could help. A “first-in-human” trial refers to the initial stage of testing a new drug or treatment in people. Before any medication…