Doctors with the Broad Institute of Harvard and MIT, the University of Hawaii Cancer Center, and the Departments of Cardiothoracic Surgery and Genome Technology at New York’s Langone Medical Center, have identified four specific genes they believe are directly linked to mesothelioma development. Scientists have long known that asbestos in the tissue can trigger genetic mutations that lead to mesothelioma. But, while past studies have focused on small sets of genes and have provided a limited view of these mutations, this new study is the first to analyze the entire gene for all possible genetic alterations. The new study involved whole exome sequencing – or a complete analysis of the DNA – on 22 malignant pleural mesothelioma patients. “Integrative analysis … Continue reading Multi-Center Study Reveals “Genomic Basis” of Mesothelioma
An analysis of chromosomal abnormalities in people with malignant mesothelioma finds that genes may play a significant role in determining where mesothelioma develops in the body. Mesothelioma is an aggressive malignancy primarily associated with exposure to asbestos dust. It’s most common site is on the pleura, the membrane that surrounds the lungs. The second most common site for mesothelioma tumors – accounting for about 30% of cases – is the peritoneal membrane that lines the abdomen. A number of studies in recent years have suggested that, like many other types of cancer, mesothelioma also has a genetic component and people with certain kinds of abnormalities may be more prone to develop it. Now, a new study conducted by Japanese pathologists … Continue reading Study Finds Genes May Influence Site of Mesothelioma Tumors
British genetic researchers say a mesothelioma patient’s genes can influence their response to chemotherapy and the knowledge may open the door for more individualized and successful mesothelioma treatments. The team from Guy’s Hospital and St. Thomas’ Hospital in London, focused on polymorphisms, genetic variations that can impact patients’ tolerance to Alimta- (pemetrexed) based chemotherapy. The combination of Alimta and a platinum derivative like cisplatin is currently the most popular first-line treatment for pleural mesothelioma. Using a genetic test called the Illumina Human Exome v 1.1 BeadChip, the researchers compared 28 polymorphisms on 11 key genes with clinical outcomes in patients with either non-small cell lung cancer or mesothelioma. All of the 136 study subjects were receiving combination chemotherapy with Alimta … Continue reading Using Genes to Predict Mesothelioma Chemotherapy Response
Could susceptibility to mesothelioma pass from parent to child through the genes? That is a question Greek scientists are trying to answer as they try to determine why some families seem to be ‘prone’ to mesothelioma. Although many other cancers are known to have a hereditary component, mesothelioma is unique in that it is known to be caused by exposure to the mineral asbestos. Inhaling or ingesting asbestos fibers can trigger a series of physiological changes that leads to mesothelioma years later. In most cases where multiple members of a family are diagnosed with mesothelioma, they are all found to have been exposed to asbestos. Children are sometimes exposed to the asbestos on a parent’s work clothes. Or several members … Continue reading Is Mesothelioma Hereditary?
The same genes that can help predict which mesothelioma patients will do well after surgery, might also be good targets for gene therapy to combat the disease. That’s the conclusion of one of the nation’s top mesothelioma experts, Dr. David Sugarbaker, and his colleagues at Brigham & Women’s Hospital in Boston. After publishing research showing that certain genes can affect patients’ post-surgical prognosis, the team looked further into the genes themselves and how they relate to mesothelioma. Mesothelioma is highly resistant to standard treatments. Gene therapy, which harnesses and uses the body’s own nature defense system, is being studied as a promising alternative. Starting with lung tissue from both healthy patients and those with malignant pleural mesothelioma, the researchers used … Continue reading Genes May be Targets for Mesothelioma Treatment