Tag Archives: mesothelioma prognosis

Protein Marker Linked to Prognosis in Peritoneal Mesothelioma

A cellular marker that helps tell cancer cells to replicate may be used to predict treatment outcomes in people with malignant peritoneal mesothelioma. That conclusion comes from a group of researchers at Australia’s University of New South Wales. The researchers tested tissue samples from 42 mesothelioma patients for the presence of Ki67, a protein associated with cell proliferation. According to the authors, Ki67 has been widely used as a prognostic indicator in other types of cancer, but has not been tested in mesothelioma. The researchers divided the tissue samples into two groups based on their level of Ki67 expression. Those with a Ki67 expression of less than 25% were put in the low category and all samples above that were … Continue reading Protein Marker Linked to Prognosis in Peritoneal Mesothelioma »

Mesothelioma Prognosis: Some Markers More Useful than Others

Deciding which treatments to try and determining whether they are working are two of the biggest challenges for patients with malignant pleural mesothelioma.  But a team of researchers in the UK is trying to make the process a little easier. They have identified three markers the say can help doctors predict prognosis in mesothelioma patients and monitor their response to treatment. The South West Area Mesothelioma and Pemetrexed trial, based in the Southwestern part of England, recruited 73 pleural mesothelioma patients between 2008 and 2011. Fifty-eight of the patients elected to undergo chemotherapy with pemetrexed (Alimta) for their mesothelioma and 15 opted only for best supportive care, without chemotherapy. Before treatment began, the researchers used PET-CT to test each patient’s baseline … Continue reading Mesothelioma Prognosis: Some Markers More Useful than Others »

Response to Talc Treatment May Predict Mesothelioma Prognosis

How well a mesothelioma patient’s lungs respond to a procedure designed to eliminate excess lung fluid may be a better predictor of survival than the stage or subtype of their cancer. A group of pathologists and thoracic surgeons in Italy came to that conclusion after evaluating the cases of 172 mesothelioma patients who underwent a procedure called talc pleurodesis or talc poudrage. Talc pleurodesis is designed to prevent a buildup of lung fluid that is common in mesothelioma patients and causes unpleasant symptoms like shortness of breath. After the lung fluid (also called pleural effusion) is drained, the space between the two pleural layers is filled with talc. The talc acts as a chemical irritant causing inflammation and fibrosis which … Continue reading Response to Talc Treatment May Predict Mesothelioma Prognosis »

Enzyme May Help Doctors Determine Mesothelioma Prognosis

Cancer researchers in New York say they have found a new way to help determine prognosis for people with malignant pleural mesothelioma. In a report in the Annals of Surgical Oncology, a team of doctors from Memorial Sloan Kettering Cancer Center say patients whose cancer cells tested positive for an enzyme called CD10 had more aggressive mesothelioma and shorter survival times. Right now, stage (a measure of how far cancer has spread in the body) and type are the primary prognostic factors for mesothelioma. People with more advanced cancer or non-epithelioid mesothelioma tend to have poorer outcomes than people with epithelioid or early-stage mesothelioma. By offering another reliable prognostic factor, the new study suggests that CD10 can help make the process more effective, which may improve … Continue reading Enzyme May Help Doctors Determine Mesothelioma Prognosis »

PET Supports Mesothelioma Diagnosis and Prognosis

Positron emission tomography (PET) is a nuclear medicine imaging technique that highlights metabolic activity in the body.  PET scanning detects gamma rays emitted by a tracer that is delivered into the body via a biologically active molecule, typically FDG, a form of glucose. FDG PET is one of the imaging tests sometimes used to help diagnose and monitor mesothelioma cancer on the pleural membrane around the lungs. Now, nuclear medicine specialists in Milan say FDG PET may be even more valuable than clinicians realize for predicting outcomes – especially in mesothelioma patients who are responsive to chemotherapy. The study involved 131 mesothelioma patients, most of whom were men, with a median age of 66. Study subjects were treated for mesothelioma … Continue reading PET Supports Mesothelioma Diagnosis and Prognosis »

Protein Biomarkers in Mesothelioma Diagnosis, Prognosis and Treatment

Three separate teams of international researchers have confirmed that proteins found in the blood can reveal some vital information for the diagnosis, treatment, and prognosis of pleural mesothelioma. These new studies on mesothelioma biomarkers indicate that all three of the studied proteins have value, but for different reasons. The most recent study comes from researchers in the Czech Republic who found that serum mesothelin, a protein overexpressed in several types of cancer, is valuable to measure the severity of mesothelioma in people who have already been diagnosed, but is unlikely to help doctors find the disease earlier. Doctors in the Department of Respiratory Medicine in Palacky University Olomouc followed 239 asbestos-exposed workers for nearly 20 years. They found that mesothelin … Continue reading Protein Biomarkers in Mesothelioma Diagnosis, Prognosis and Treatment »

FDG PET-CT Results Could Lead to Improved Mesothelioma Treatment

patient

In a recent study, researchers say a better understanding of certain diagnostic criteria could result in more targeted treatments for malignant mesothelioma. In a recent published report, doctors from the medical school at Dicle University in Diyarbakir, Turkey measured the relationship between PET-CT scan results and survival in 177 patients with malignant pleural mesothelioma. The patients were diagnosed between April 2007 and April 2011. They had a mean age of 55.4 and most (56%) were male. Patients in the study all had FDG PET-CT scans before beginning their mesothelioma treatment. FDG PET-CT scanning is a powerful imaging tool for mesothelioma and other cancers that combines a radioactive tracer with a combination of positron emission tomography and computed tomography scanning.  Because … Continue reading FDG PET-CT Results Could Lead to Improved Mesothelioma Treatment »

NUMB Gene May Suppress Mesothelioma

DNA

Researchers at Shandong University in China have pinpointed the connection between low levels of the protein NUMB and a poor mesothelioma prognosis. NUMB is known to act as an anticancer protein in part by binding to the tumor suppressor p53 and preventing its breakdown. Low levels of the NUMB protein have been linked to several types of cancer. In the latest study, published in Oncology Reports, researchers measured the expression of NUMB in 39 tissue samples of epithelioid mesothelioma. The results were compared using immunohistochemistry (protein testing) to 22 normal pleural tissues. NUMB was found to be significantly lower in the mesothelioma cells and the tissue samples with the lowest expression of NUMB were associated with the poorest prognosis. At the … Continue reading NUMB Gene May Suppress Mesothelioma »